Hepatocyte growth factor

Hepatocyte growth factor

Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing. [cite book | title=Proteoglycans: structure, biology and molecular interactions | author=Gallagher, J.T., Lyon, M. | chapter=Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens | editor=Iozzo, M, V. | year=2000 | publisher=Marcel Dekker Inc. New York, New York | pages=27-59]

section_title =
summary_text = Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [cite web | title = Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3082| accessdate = ]


Further reading

citations =
*cite journal | author=Nakamura T |title=Structure and function of hepatocyte growth factor. |journal=Prog. Growth Factor Res. |volume=3 |issue= 1 |pages= 67–85 |year= 1992 |pmid= 1838014 |doi=
*cite journal | author=Ware LB, Matthay MA |title=Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=282 |issue= 5 |pages= L924–40 |year= 2002 |pmid= 11943656 |doi= 10.1152/ajplung.00439.2001
*cite journal | author=Funakoshi H, Nakamura T |title=Hepatocyte growth factor: from diagnosis to clinical applications. |journal=Clin. Chim. Acta |volume=327 |issue= 1-2 |pages= 1–23 |year= 2003 |pmid= 12482615 |doi=
*cite journal | author=Skibinski G |title=The role of hepatocyte growth factor/c-met interactions in the immune system. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=51 |issue= 5 |pages= 277–82 |year= 2004 |pmid= 14626426 |doi=
*cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776–84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530
*cite journal | author=Hurle RA, Davies G, Parr C, "et al." |title=Hepatocyte growth factor/scatter factor and prostate cancer: a review. |journal=Histol. Histopathol. |volume=20 |issue= 4 |pages= 1339–49 |year= 2006 |pmid= 16136515 |doi=
*cite journal | author=Kemp LE, Mulloy B, Gherardi E |title=Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 414–7 |year= 2006 |pmid= 16709175 |doi= 10.1042/BST0340414

ee also

* growth factor
* hepatocyte growth factor receptor (HGFR)

External links


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