C-Fos

In molecular biology, c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at the C-terminus. Transcription of c-Fos is upregulated in response to many extracellular signals, e.g. growth factors. Additionally, phosphorylation by MAPK, PKA, PKC or cdc2 alters the activity and stability of c-Fos. Members of the Fos family dimerise with Jun to form the AP-1 transcription factor, which upregulates transcription of a diverse range of genes involved in everything from proliferation and differentiation to defense against invasion and cell damage.

The AP-1 complex has been implicated in transformation and progression of cancer, and both Fos and Jun were first discovered in rat fibroblasts.

The viral homologue of c-Fos, v-Fos, is found in the retrovirus Finkel–Biskis–Jinkins murine osteogenic sarcoma virus.

Neuroscientists measure expression of c-fos as an indirect marker of neuronal activity because c-fos is often expressed when neurons fire action potentials.

See also

*Leptomycin
*Jun
*Egr-1

Further reading

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citations =
*cite journal | author=Murphy LC, Alkhalaf M, Dotzlaw H, "et al." |title=Regulation of gene expression in T-47D human breast cancer cells by progestins and antiprogestins. |journal=Hum. Reprod. |volume=9 Suppl 1 |issue= |pages= 174–80 |year= 1994 |pmid= 7962462 |doi=
*cite journal | author=Pompeiano M, Cirelli C, Arrighi P, Tononi G |title=c-Fos expression during wakefulness and sleep. |journal=Neurophysiologie clinique = Clinical neurophysiology |volume=25 |issue= 6 |pages= 329–41 |year= 1997 |pmid= 8904195 |doi= 10.1016/0987-7053(96)84906-9
*cite journal | author=Herrera DG, Robertson HA |title=Activation of c-fos in the brain. |journal=Prog. Neurobiol. |volume=50 |issue= 2-3 |pages= 83–107 |year= 1997 |pmid= 8971979 |doi=
*cite journal | author=Velazquez Torres A, Gariglio Vidal P |title= [Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus] |journal=Rev. Invest. Clin. |volume=54 |issue= 3 |pages= 231–42 |year= 2002 |pmid= 12183893 |doi=

References

# Karin Milde-Langosch, 2005. The Fos family of transcription factors and their role in tumourigenesis. "European Journal of Cancer" 41(16):2449-2461. [http://dx.doi.org/10.1016/j.ejca.2005.08.008 Abstract + Full Text]

External links

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