- AP2B1
Adaptor-related protein complex 2, beta 1 subunit, also known as AP2B1, is a human
gene .cite web | title = Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=163| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=163| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kirchhausen T |title=Clathrin. |journal=Annu. Rev. Biochem. |volume=69 |issue= |pages= 699–727 |year= 2000 |pmid= 10966473 |doi= 10.1146/annurev.biochem.69.1.699
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Ponnambalam S, Robinson MS, Jackson AP, "et al." |title=Conservation and diversity in families of coated vesicle adaptins. |journal=J. Biol. Chem. |volume=265 |issue= 9 |pages= 4814–20 |year= 1990 |pmid= 1969413 |doi=
*cite journal | author=Gallusser A, Kirchhausen T |title=The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. |journal=EMBO J. |volume=12 |issue= 13 |pages= 5237–44 |year= 1994 |pmid= 8262066 |doi=
*cite journal | author=Druck T, Gu Y, Prabhala G, "et al." |title=Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. |journal=Genomics |volume=30 |issue= 1 |pages= 94–7 |year= 1996 |pmid= 8595912 |doi= 10.1006/geno.1995.0016
*cite journal | author=Greenberg ME, Bronson S, Lock M, "et al." |title=Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. |journal=EMBO J. |volume=16 |issue= 23 |pages= 6964–76 |year= 1998 |pmid= 9384576 |doi= 10.1093/emboj/16.23.6964
*cite journal | author=Lim DS, Kirsch DG, Canman CE, "et al." |title=ATM binds to beta-adaptin in cytoplasmic vesicles. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10146–51 |year= 1998 |pmid= 9707615 |doi=
*cite journal | author=Greenberg M, DeTulleo L, Rapoport I, "et al." |title=A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1239–42 |year= 1999 |pmid= 9811611 |doi=
*cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, "et al." |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350–61 |year= 1999 |pmid= 9882340 |doi=
*cite journal | author=Owen DJ, Vallis Y, Pearse BM, "et al." |title=The structure and function of the beta 2-adaptin appendage domain. |journal=EMBO J. |volume=19 |issue= 16 |pages= 4216–27 |year= 2000 |pmid= 10944104 |doi= 10.1093/emboj/19.16.4216
*cite journal | author=Fan GH, Yang W, Wang XJ, "et al." |title=Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization. |journal=Biochemistry |volume=40 |issue= 3 |pages= 791–800 |year= 2001 |pmid= 11170396 |doi=
*cite journal | author=Swigut T, Shohdy N, Skowronski J |title=Mechanism for down-regulation of CD28 by Nef. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1593–604 |year= 2001 |pmid= 11285224 |doi= 10.1093/emboj/20.7.1593
*cite journal | author=Laporte SA, Miller WE, Kim KM, Caron MG |title=beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9247–54 |year= 2002 |pmid= 11777907 |doi= 10.1074/jbc.M108490200
*cite journal | author=Collins BM, McCoy AJ, Kent HM, "et al." |title=Molecular architecture and functional model of the endocytic AP2 complex. |journal=Cell |volume=109 |issue= 4 |pages= 523–35 |year= 2002 |pmid= 12086608 |doi=
*cite journal | author=He G, Gupta S, Yi M, "et al." |title=ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44044–9 |year= 2003 |pmid= 12221107 |doi= 10.1074/jbc.M208539200
*cite journal | author=Cayrol C, Cougoule C, Wright M |title=The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1. |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 5 |pages= 720–30 |year= 2003 |pmid= 12419313 |doi=
*cite journal | author=Yao D, Ehrlich M, Henis YI, Leof EB |title=Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4001–12 |year= 2003 |pmid= 12429842 |doi= 10.1091/mbc.02-07-0104
*cite journal | author=Kalthoff C, Groos S, Kohl R, "et al." |title=Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4060–73 |year= 2003 |pmid= 12429846 |doi= 10.1091/mbc.E02-03-0171PBB_Controls
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