- Milacemide
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Milacemide N2-PentylglycinamideOther names2-(Pentylamino)acetamideIdentifiers CAS number 76990-56-2 PubChem 53569 ChemSpider 48376 UNII 0HXT24RECU Jmol-3D images Image 1 - O=C(N)CNCCCCC
- InChI=1S/C7H16N2O/c1-2-3-4-5-9-6-7(8)10/h9H,2-6H2,1H3,(H2,8,10)
Key: GJNNXIYZWIZFRH-UHFFFAOYSA-N
InChI=1/C7H16N2O/c1-2-3-4-5-9-6-7(8)10/h9H,2-6H2,1H3,(H2,8,10)
Key: GJNNXIYZWIZFRH-UHFFFAOYAI
Properties[1] Molecular formula C7H16N2O Molar mass 144.21 g mol−1 Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references Milacemide is a MAO-B inhibitor and glycine prodrug.[2] It has been studied for its effects on human memory and as a potential treatment for the symptoms of Alzheimer's disease.[3] Early clinical trials, however, showed no positive results.[2]
References
- ^ PubChem 53569
- ^ a b Dysken, MW; Mendels, J, LeWitt, P, Reisberg, B, Pomara, N, Wood, J, Skare, S, Fakouhi, JD, Herting, RL (1992 May). "Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type.". Journal of the American Geriatrics Society 40 (5): 503–6. PMID 1634705. http://www.ncbi.nlm.nih.gov/pubmed/1634705.
- ^ Harris, Carol Turkington ; foreword by Joseph R. (2002). The encyclopedia of the brain and brain disorders (2nd ed. ed.). New York, NY: Facts on File. ISBN 081604774X. http://www.scribd.com/doc/10098801/The-Encyclopedia-of-the-Brain-and-Brain-Disorders.
Glycinergics Receptor
ligandsAgonistsAlanine • Cycloserine • Dimethylglycine • Glycine • Hypotaurine • Methylglycine (Sarcosine) • Milacemide • Serine • Taurine • Trimethylglycine (Betaine)Reuptake
inhibitorsPlasmalemmalGlyT1 inhibitorsGlyT2 inhibitorsVIAAT InhibitorsEnzyme
inhibitorsSHMT InhibitorsGDC InhibitorsDAAO InhibitorsOthers Categories:- Amino acid derivatives
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