Systematic (IUPAC) name
Clinical data
Trade names Nardil
AHFS/ monograph
MedlinePlus a682089
Pregnancy cat. B3(AU) C(US)
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Metabolism Liver
Half-life 11.6 hours
Excretion Urine
CAS number 51-71-8 YesY
ATC code N06AF03
PubChem CID 3675
DrugBank DB00780
ChemSpider 3547 YesY
UNII O408N561GF YesY
KEGG D08349 YesY
Chemical data
Formula C8H12N2 
Mol. mass 136.19 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Phenelzine (Nardil, Nardelzine) is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class which is used as an antidepressant and anxiolytic. Along with tranylcypromine and isocarboxazid, phenelzine is one of the few non-selective MAOIs still in widespread clinical use.



Phenelzine is used primarily in the treatment of major depressive disorder (MDD). Patients with depressive symptomology characterized as "atypical", "nonendogenous", and/or "neurotic", have been reported to respond particularly well to phenelzine.[1] The medication has also been found to be useful in patients who do not respond favorably to first and second-line treatments for depression, or are said to be "treatment-resistant".[2] In addition to being a recognized treatment for major depressive disorder, phenelzine has been found in studies to be effective in treating dysthymia,[3] bipolar depression (BD),[4] panic disorder (PD),[5] social anxiety disorder (SAD),[6] bulimia,[7] and post-traumatic stress disorder (PTSD).[8]



Phenelzine is a non-selective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). It inhibits both of the respective isoforms of MAO, MAO-A and MAO-B, and does so almost equally, with slight preference for the former. By inhibiting MAO, phenelzine prevents the breakdown of the monoamine neurotransmitters serotonin, melatonin, norepinephrine, epinephrine, and dopamine, as well as the trace amine neuromodulators such as phenethylamine, tyramine, octopamine, and tryptamine. This leads to an increase in the extracellular concentrations of these neurochemicals and therefore an alteration in neurochemistry and subsequently neurotransmission. It is this action that is thought to be the primary mediator in phenelzine's therapeutic benefits.

Notably, although phenelzine inhibits the breakdown of norepinephrine and epinephrine (which in concept should lead to increased levels of these two respective neurotransmitters), it actually typically significantly decreases their overall activity with time via a complex interaction with octopamine. This is the cause of the side effect of orthostatic hypotension commonly seen with phenelzine and the other MAOIs. Importantly, it has been demonstrated that the antidepressant effects of serotonin are actually mediated through norepinephrine.[9] As a result, this depletion of norepinephrine and epinephrine may significantly inhibit the full therapeutic potential of phenelzine and the other MAOIs. For this reason, augmenting with an adrenergic agent such as a norepinephrine reuptake inhibitor (NRI) or releasing agent (NRA) in conjunction may be desirable, though strict professional supervision is advised to minimize the risk of a potentially dangerous drug interaction such as hypertensive crisis.

Phenelzine and its metabolites also inhibit at least two other enzymes to a lesser extent, of which are alanine transaminase (ALA-T),[10] and γ-Aminobutyric acid transaminase (GABA-T),[11] the latter of which is not caused by phenelzine itself, but by a phenelzine metabolite phenylethylidenehydrazine (PEH). By inhibiting ALA-T and GABA-T, phenelzine causes an increase in the alanine and GABA levels in the brain and body. GABA is the major inhibitory neurotransmitter in the mammalian central nervous system, and is very important for the normal suppression of anxiety and stress, as well as keeping depression at bay. It is thought that phenelzine's action in increasing GABA concentrations may significantly contribute to its antidepressant, and especially, anxiolytic/antipanic properties, the latter of which have typically been considered superior to those of other antidepressants. As for ALA-T inhibition, though the consequences of disabling this enzyme are currently not well understood, there is some evidence to suggest that it is this action of the hydrazines (including phenelzine) which may be responsible for the occasional incidence of hepatitis and liver failure.

Phenelzine has also been shown to metabolize to phenethylamine (PEA).[12] PEA acts as a releasing agent of norepinephrine and dopamine, and produces effects very similar to those of amphetamine, though with markedly different pharmacokinetics such as a far shorter duration of action. Phenelzine's enhancement of PEA levels may contribute further to its overall antidepressant effects to some degree. In addition, phenethylamine is a substrate for MAO-B, and treatment with MAOIs that inhibit MAO-B such as phenelzine have been shown to consistently and significantly elevate its concentrations.

Like many other antidepressants, phenelzine usually requires several weeks of treatment to achieve full therapeutic effects. The reason for this delay has not fully been elucidated, but it is believed to be due to many factors, including achieving steady-state levels of MAO inhibition and the resulting adaptations in mean neurotransmitter levels, as well as the possibility of necessary desensitization of autoreceptors which normally inhibit the release of neurotransmitters like serotonin and dopamine. Typically, a therapeutic response to MAOIs is believed to be associated with an inhibition of at least 80-85% of monoamine oxidase activity.


Phenelzine 15 mg tablets.

Phenelzine is administered orally in the form of phenelzine sulfate and is rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration is 43 minutes and half-life is 11.6 hours. Unlike most other drugs, phenelzine irreversibly disables MAO, and as a result, it does not necessarily need to be present in the blood at all times for its effects to be sustained. Because of this, upon phenelzine treatment being ceased, its effects typically do not actually wear off until the body replenishes its enzyme stores, a process which can take as long as 2–3 weeks.

Phenelzine is metabolized primarily in the liver and its metabolites are excreted in the urine. Oxidation is the primary routine of metabolism, and the major metabolites are phenylacetic acid and parahydroxyphenylacetic acid, recovered as about 73% of the excreted dose of phenelzine in the urine over the course of 96 hours after single doses. Acetylation to N2-acetylphenelzine is a minor pathway. Phenelzine may also interact with cytochrome P450 enzymes, inactivating these enzymes through formation of a heme adduct. Two other minor metabolites of phenelzine, as mentioned above, include phenylethylidenehydrazine and phenethylamine.


Phenelzine is made relatively easily through the reaction of 2-phenylethylbromide with hydrazine.[13][14][15]

Adverse effects

Common side effects of phenelzine may include dizziness, blurry vision, dry mouth, headache, lethargy, sedation, somnolence, insomnia, anorexia, weight gain or loss, nausea and vomiting, diarrhea, constipation, urinary retention, mydriasis, muscle tremors, hyperthermia, sweating, hypertension or hypotension, orthostatic hypotension, paresthesia, hepatitis, and sexual dysfunction (consisting of loss of libido and anorgasmia). Rare side effects usually only seen in susceptible individuals may include hypomania or mania, psychosis, and acute liver failure, the latter of which is usually only seen in people with pre-existing liver damage, old age, alcohol consumption, or viral infection.[16]


The MAOIs are infamous for their problematic food restrictions and drug interactions. Hypertensive crisis may result from the overconsumption of tyramine-containing foods. As a result, patients on phenelzine and other MAOIs must avoid excess quantities of certain foods that contain tyramine such as aged cheeses and cured meats, among others. Serotonin syndrome may result from an interaction with certain drugs which increase serotonin activity such as selective serotonin reuptake inhibitors and pethidine (known as meperidine in the US). Several deaths have been reported due to drug interaction-related serotonin syndrome such as the case of Libby Zion.

Phenelzine has also been linked to vitamin B6 deficiency. It reacts with vitamin B6 via an unknown enzyme to form a biologically inert metabolite. Both phenelzine and vitamin B6 are rendered inactive upon this reaction occurring. For this reason, it is recommended to supplement with vitamin B6 while taking phenelzine. High doses of vitamin B6 may significantly lower phenelzine levels and subsequently inhibit its therapeutic benefits, however, and thus, excess quantities of vitamin B6 should be avoided. It may be advisable to dose them separately during opposite intervals of the day (e.g., take one, then take the other 12 hours later) to avoid interaction as much as possible.

See also


  1. ^ Parke-Davis Division of Pfizer Inc. (2007). Nardil(R) (Phenelzine sulfate tablets, USP), labeling information. Retrieved December 14, 2009 from the U.S. Food and Drug Administration's Web site:
  2. ^ Fiedorowicz, J. G.; Swartz (2004). "The Role of Monoamine Oxidase Inhibitors in Current Psychiatric Practice". Journal of psychiatric practice 10 (4): 239–248. doi:10.1097/00131746-200407000-00005. PMC 2075358. PMID 15552546.  edit
  3. ^ Vallejo, J.; Gasto, C.; Catalan, R.; Salamero, M. (1987). "Double-blind study of imipramine versus phenelzine in Melancholias and Dysthymic Disorders". The British journal of psychiatry : the journal of mental science 151 (5): 639–642. doi:10.1192/bjp.151.5.639. PMID 3446308.  edit
  4. ^ Quitkin, F. M.; Mcgrath, P.; Liebowitz, M. R.; Stewart, J.; Howard, A. (1981). "Monoamine oxidase inhibitors in bipolar endogenous depressives". Journal of clinical psychopharmacology 1 (2): 70–74. doi:10.1097/00004714-198103000-00005. PMID 7028797.  edit
  5. ^ Buigues, J.; Vallejo, J. (1987). "Therapeutic response to phenelzine in patients with panic disorder and agoraphobia with panic attacks". The Journal of clinical psychiatry 48 (2): 55–59. PMID 3542985.  edit
  6. ^ Blanco, C.; Schneier, F.; Schmidt, A.; Blanco-Jerez, C.; Marshall, R.; Sánchez-Lacay, A.; Liebowitz, M. (2003). "Pharmacological treatment of social anxiety disorder: a meta-analysis". Depression and anxiety 18 (1): 29–40. doi:10.1002/da.10096. PMID 12900950.  edit
  7. ^ Walsh, B. T.; Gladis; Roose; Stewart; Stetner; Glassman (1988). "Phenelzine vs placebo in 50 patients with bulimia". Archives of general psychiatry 45 (5): 471–475. PMID 3282482.  edit
  8. ^ Frank, J. B.; Kosten; Giller El; Dan (1988). "A randomized clinical trial of phenelzine and imipramine for posttraumatic stress disorder". The American journal of psychiatry 145 (10): 1289–1291. PMID 3048121.  edit
  9. ^ Cryan, J.; O'Leary, O.; Jin, S.; Friedland, J.; Ouyang, M.; Hirsch, B.; Page, M.; Dalvi, A. et al. (2004). "Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors". Proceedings of the National Academy of Sciences of the United States of America 101 (21): 8186–8191. Bibcode 2004PNAS..101.8186C. doi:10.1073/pnas.0401080101. PMC 419578. PMID 15148402.  edit
  10. ^ Tanay, V. A.; Parent, M. B.; Wong, J. T.; Paslawski, T.; Martin, I. L.; Baker, G. B. (2001). "Effects of the antidepressant/antipanic drug phenelzine on alanine and alanine transaminase in rat brain". Cellular and molecular neurobiology 21 (4): 325–339. doi:10.1023/A:1012697904299. PMID 11775064.  edit
  11. ^ Mckenna, K. F.; Mcmanus, D. J.; Baker, G. B.; Coutts, R. T. (1994). "Chronic administration of the antidepressant phenelzine and its N-acetyl analogue: effects on GABAergic function". Journal of neural transmission. Supplementum 41: 115–122. PMID 7931216.  edit
  12. ^ Dyck LE, Durden DA, Boulton AA (June 1985). "Formation of beta-phenylethylamine from the antidepressant, beta-phenylethylhydrazine". Biochemical Pharmacology 34 (11): 1925–9. doi:10.1016/0006-2952(85)90310-7. PMID 4004908. 
  13. ^ J.H. Biel, U.S. Patent 3,000,903 (1961).
  14. ^ J.H. Biel, A.E. Drukker, et al. J. Am. Chem. Soc., 81, 2805 (1959).
  15. ^ T.S. Gardner, E. Wenis, U.S. Patent 2,908,688 (1959).
  16. ^ Gómez-Gil, E.; Salmerón; Mas (1996). "Phenelzine-induced fulminant hepatic failure". Annals of internal medicine 124 (7): 692–693. PMID 8607601.  edit

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  • phenelzine — /fen l zeen /, n. Pharm. a potent monoamine oxidase inhibitor, C8H12N2, used to treat certain kinds of depression. [1955 60; PHEN + E(THY)L + (HYDRA)ZINE] * * * …   Universalium

  • phenelzine — noun A monoamine oxidase inhibitor, used as an antidepressant, chemical formula CHN …   Wiktionary

  • phenelzine — phen·el·zine fen əl .zēn n a monoamine oxidase inhibitor C8H12N2 that suppresses REM sleep and is used esp. as an antidepressant drug see NARDIL * * * n. a drug used to relieve depression and anxiety (see MAO inhibitor). It is administered by… …   Medical dictionary

  • phenelzine — phen·el·zine …   English syllables

  • phenelzine — n. a drug used to relieve depression (see MAO inhibitor). It is administered by mouth; side effects include dizziness and a fall in blood pressure on standing up. Trade names: Nardil …   The new mediacal dictionary

  • phenelzine — noun monoamine oxidase inhibitor (trade name Nardil) used to treat clinical depression • Syn: ↑Nardil • Usage Domain: ↑trade name (for: ↑Nardil) • Hypernyms: ↑monoamine oxidase inhibitor, ↑ …   Useful english dictionary

  • phenelzine sulfate — A monoamine oxidase inhibitor used as an antidepressant. * * * phen·el·zine sul·fate (fenґəl zēn) [USP] a monoamine oxidase inhibitor used as an antidepressant and in the prophylaxis of migraine; administered orally …   Medical dictionary

  • PLZ — phenelzine …   Medical dictionary

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  • Hydrazine (antidepressant) — Iproniazid, the first hydrazine MAOI to be discovered, and the first antidepressant drug ever marketed. The hydrazine antidepressants are a group of non selective and irreversible monoamine oxidase inhibitors (MAOIs) that were discovered and… …   Wikipedia

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