Loreclezole

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IUPAC_name = 1- [(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl] -1,2,4-triazole

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CAS_number = 117857-45-1
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PubChem = 3034012
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C=10|H=6|Cl=3|N=3
molecular_weight = 274.534 g/mol
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Loreclezole is a sedative and an anticonvulsant which acts as a GABA agonist. It binds allosterically to the GABA_A receptor. [ [http://www.ionchannels.org/showabstract.php?pmid=8183949 The modulatory action of loreclezole at the gamma-aminobutyric acid type A recep ] ] The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant. [ [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17585957&ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Valerenic acid potentiates and inhibits GABA(A) re... [Neuropharmacology. 2007 - PubMed Result ] ]

References