Zuclopenthixol

Zuclopenthixol

Systematic (IUPAC) name
cis-(Z)-2-(4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethanol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C
Legal status	℞ Prescription only
Routes	Oral, IM
Pharmacokinetic data
Bioavailability	49% (oral)
Protein binding	98%
Metabolism	Hepatic (CYP2D6-mediated)
Half-life	20 hours (oral), 19 days (IM)
Excretion	Feces
Identifiers
CAS number	53772-83-1 Y 85721-05-7 (acetate) 64053-00-5 (decanoate)
ATC code	N05AF05
PubChem	CID 5311507
DrugBank	DB01624
ChemSpider	4470984 Y
UNII	47ISU063SG Y
KEGG	D03556 Y
ChEBI	CHEBI:51364 N
ChEMBL	CHEMBL53904 Y
Chemical data
Formula	C22H25ClN2OS
Mol. mass	400.965 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5- Y Key:WFPIAZLQTJBIFN-DVZOWYKESA-N Y
N(what is this?)  (verify)

Zuclopenthixol (Cisordinol, Clopixol, Acuphase), also known as zuclopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced in 1962 by Lundbeck.^[1]

Zuclopenthixol is the cis-isomer of clopenthixol.^[2]

Uses/Forms

Cisordinol

Zuclopenthixol is available in three major preparations:

• As zuclopenthixol decanoate (Clopixol), it is a long acting intramuscular injection. Its main use is as a long acting injection given two or three times weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness.^[3] In some countries this can be mandated by Court order for a lengthy period of time, sometimes years, at the request of the psychiatrist. There is some evidence it may be more helpful in managing aggressive behaviour.^[4]

• As zuclopenthixol acetate (Clopixol, Acuphase), it is a shorter acting intramuscular injection used in the acute sedation of psychotic inpatients. The effect peaks at 48–72 hours providing 2–3 days of sedation.^[5]

• As zuclopenthixol dihydrochloride (Clopixol), it is a tablet used in the treatment of schizophrenia in those who are compliant with oral medication.^[6]

It is also used in the treatment of acute bipolar mania.

Dosing

As a long acting injection, zuclopenthixol decanoate comes in a 200 mg and 500mg ampoule. Doses can vary from 50 mg 4 weekly to the maximum licensed dose of 600 mg weekly. In general, the lowest effective dose to prevent relapse is preferred. The interval may be shorter as a patient starts on the medication before extending to 3 weekly intervals subsequently. The dose should be reviewed and reduced if side effects occur, though in the short term an anticholinergic medication benztropine may be helpful for tremor and stiffness, while diazepam may be helpful for akathisia. 100 mg of zuclopenthixol decanoate is roughly equivalent to 20 mg of flupentixol decanoate or 12.5 mg of fluphenazine decanoate.

In acutely psychotic and agitated inpatients, 50 - 200 mg of zuclopenthixol acetate may be given for a calming effect over the subsequent three days, with a maximum dose of 400 mg in total to be given. As it is a long-acting medication, care must be taken not to give an excessive dose.

In oral form zuclopenthixol is available in 10, 25 and 40 mg tablets, with a dose range of 20–60 mg daily.

Pharmacology

Zuclopenthixol mainly acts by antagonism of D₁ and D₂ receptors, though it also has some antihistamine effects, among other properties.

Side effects

Chronic administration of zuclopenthixol (30mg/kg/day for two years) in rats resulted in small, but significant, increases in the incidence of thyroid parafollicular carcinomas and, in females, of mammary adenocarcinomas and of pancreatic islet cell adenomas and carcinomas. An increase in the incidence of mammary adenocarcinomas is a common finding for D2 antagonists which increase prolactin secretion when administered to rats. An increase in the incidence of pancreatic islet cell tumours has been observed for some other D2 antagonists. The physiological differences between rats and humans with regard to prolactin make the clinical significance of these findings unclear.

Other side effects are similar to many other typical antipsychotics, namely extrapyramidal symptoms as a result of dopamine blockade in subcortical areas of the brain. This may result in symptoms similar to those seen in Parkinsons Disease and include a restlessness and inability to sit still known as akathisia, a slow tremor and stiffness of the limbs.^[6] Zuclopenthixol is thought to be more sedating than the related flupentixol, though possibly less likely to induce extrapyramidal symptoms than other typical depots.^[3] As with other dopamine antagonists, zuclopenthixol may sometimes elevate prolactin levels; this may occasionally result in amenorrhoea or galactorrhoea in severe cases. Neuroleptic malignant syndrome is a rare but potentially fatal side effect. Any unexpected deterioration in mental state with confusion and muscle stiffness should be seen by a physician.

See also

• Typical antipsychotic
• Thioxanthene

References

1. ^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 3-527-31058-4. http://books.google.com/?id=yXD4QA-Y_Z0C&lpg=PA520&pg=PA516#v=onepage. 
2. ^ Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1. http://books.google.com/?id=Cb6BOkj9fK4C&lpg=PA410&pg=PA410#v=onepage. 
3. ^ ^{a b} da Silva Freire Coutinho E, Fenton M, Quraishi SN (1999). "Zuclopenthixol decanoate for schizophrenia". The Cochrane Database of Systematic Reviews. John Wiley and Sons, Ltd.. doi:10.1002/14651858.CD001164. http://www.cochrane.org/reviews/en/ab001164.html. Retrieved 2007-06-12. 
4. ^ Haessler F, Glaser T, Beneke M, Pap AF, Bodenschatz R, Reis O (2007). "Zuclopenthixol in adults with intellectual disabilities and aggressive behaviours". British Journal of Psychiatry 190 (5): 447–448. doi:10.1192/bjp.bp.105.016535. PMID 17470962 
5. ^ Lundbeck P/L (1991). "Clopixol Acuphase 50 mg/mL Injection Clopixol Acuphase 100 mg / 2 mL Injection". Lundbeck P/L. http://home.intekom.com/pharm/lundbeck/clopixac.html. Retrieved 2007-06-12. 
6. ^ ^{a b} Kumar A, Strech D (2005). "Zuclopenthixol dihydrochloride for schizophrenia". The Cochrane Database of Systematic Reviews. John Wiley and Sons, Ltd.. doi:10.1002/14651858.CD005474. http://www.cochrane.org/reviews/en/ab005474.html. Retrieved 2007-06-12.