Thioxanthene

Thioxanthene

Thioxanthene is a molecule in which the oxygen atom in xanthene is replaced with a sulfur atom. Various thioxanthene derivatives are used in the treatment of schizophrenia and psychosis. The activity of these compounds is related to their ability to inhibition transmission at D2 receptors, in the brain.

Thioxanthene derivatives include:
* Chlorprothixene
* Flupenthixol
* Thiothixene
* Zuclopenthixol

The thioxanthene class of neuroleptic antipsychotic psychotropics is closely related to the phenothiazines, with the nitrogen at position 10 in the phenothiazines, (opposite the sulfur atom in the middle ring), replaced by a carbon atom with a double bond to the side chain. ["Goodman and Gilman" ]

References

External links

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* [http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202564.html MedlinePlus]


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Look at other dictionaries:

  • Thioxanthène — Général No CAS …   Wikipédia en Français

  • Thioxanthene — One of a group of drugs with antipsychotic activity which act by blocking postsynaptic (after the nerve) receptors for dopamine (a chemical that nerves use to communicate with one another) in the brain. Examples include: thiothixene (brand name:… …   Medical dictionary

  • thioxanthene — /thuy euh zan theen/, n. Pharm. any of a class of antipsychotics, as thiothixene, used to relieve symptoms of severe psychiatric disorders. [THIO + XANTH + ENE] * * * …   Universalium

  • thioxanthene — noun The tricyclic heterocycle (sulfur analogue of xanthene) consisting of two benzene rings fused to that of thiopyran …   Wiktionary

  • thioxanthene — n.; see antipsychotic …   The new mediacal dictionary

  • thioxanthene — /thuy euh zan theen/, n. Pharm. any of a class of antipsychotics, as thiothixene, used to relieve symptoms of severe psychiatric disorders. [THIO + XANTH + ENE] …   Useful english dictionary

  • Тиоксантен (Thioxanthene) — см. Средство антипсихотическое. Источник: Медицинский словарь …   Медицинские термины

  • Thiothixene — Systematic (IUPAC) name (9Z) N,N dimethyl 9 [3 (4 methylpiperazin 1 yl)propylidene] 9H thioxanthene 2 sulfonamide Clinical data Trade names …   Wikipedia

  • Chlorprothixene — Systematic (IUPAC) name (Z) 3 (2 chlorothioxanthen 9 ylidene) N, N dimethyl propan 1 amine Clinical data …   Wikipedia

  • Clopenthixol — cis,trans mixture Systematic (IUPAC) name cis,trans 2 [4 [3 (2 chlorothioxanthen 9 ylidene) propyl]piperazin 1 yl]ethanol Clinical data …   Wikipedia

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