VUF-6002

Drugbox
IUPAC_name = 1- [(5-Chloro-1H-benzimidazol-2-yl)carbonyl] -4-methylpiperazine

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CAS_number= 869497-75-6
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PubChem= 10446295
DrugBank=
C=13 | H=15 | Cl=1 | N=4 | O=1
molecular_weight = 278.737 g/mol
smiles = n2c1ccc(Cl)cc1nc2C(=O)N3CCN(C)CC3
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VUF-6002 (JNJ 10191584) is a drug which acts as a potent and selective antagonist at the histamine H4 receptor. [Zhang M, Thurmond RL, Dunford PJ. The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders. "Pharmacology and Therapeutics". 2007 Mar;113(3):594-606. PMID 17275092] It has antiinflammatory and analgesic effects in animal studies of acute inflammation. [Coruzzi G, Adami M, Guaita E, de Esch IJ, Leurs R. Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. "European Journal of Pharmacology". 2007 Jun 1;563(1-3):240-4. PMID 17382315]

References