- Silodosin
drugbox
IUPAC_name = 1-(3-hydroxypropyl)-5- [(2R)- 2- [2- [2-(2,2,2-trifluoroethoxy) phenoxy] ethylamino] propyl] -7-indolinecarboxamide
CAS_number = 160970-54-7
ATC_prefix =
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PubChem = 5312125
DrugBank =
C = 25 |H = 33 |F = 3 |N = 3 |O = 4
molecular_weight = 495.534g/mol
smiles = Clc1ccc2ccc(/C=C/c3cccc(c3)C(CCc3ccccc3C(C)(C)O)SCC3(CC3)CC(=O)O)nc2c1
bioavailability =
protein_bound =
metabolism =
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routes_of_administration = OralSilodosin is an α1-
adrenoceptor antagonistcite journal |author=Yoshida M, Homma Y, Kawabe K |title=Silodosin, a novel selective alpha 1A-adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia |journal=Expert Opin Investig Drugs |volume=16 |issue=12 |pages=1955–65 |year=2007 |month=December |pmid=18042003 |doi=10.1517/13543784.16.12.1955 |url=http://www.expertopin.com/doi/abs/10.1517/13543784.16.12.1955] with high uroselectivity. It appears to be more effective thantamsulosin in relieving urinary symptoms associated withbenign prostatic hyperplasia (BPH).Fact|date=August 2008History
Silodosin received its first marketing approval in Japan in May 2006 under the tradename Urief, which is jointly marketed by Kissei Pharmaceutical Co., Ltd. and Daiichi Sankyo Pharmaceutical Co., Ltd.
Kissei licensed the US, Canadian, and Mexican rights for silodosin to Watson Pharmaceuticals, Inc. in
2004 .On
February 12 ,2008 , Watson announced that the New Drug Application submitted to theUnited States Food and Drug Administration for silodosin has been accepted for filing. FDA approved this drug on October 9th, 2008. [cite web |url=http://www.drugs.com/nda/silodosin_080212.html |title=Drugs.com, Watson Announces Silodosin NDA Accepted for Filing by FDA for the Treatment of Benign Prostatic Hyperplasia |accessdate=2008-02-13 |format= |work= ]References
External links
* [http://ir.watsonpharm.com/phoenix.zhtml?c=65778&p=irol-newsArticle&ID=719690&highlight= Watson Pharm., Inc.- Press Release]
* [http://www.medscape.com/viewarticle/548919 Medspace.com atricle]
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