Butyrophenone

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IUPACName=1-phenylbutan-1-one
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PubChem=10315
SMILES=CCCC(=O)C1=CC=CC=C1
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Formula=C₁₀H₁₂O
MolarMass=148.202
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Butyrophenone is a chemical compound (a ketone); some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.

Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.

Examples include:

* Haloperidol, the most widely-used classical antipsychotic drug in this class
* Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
* Benperidol, the most potent commonly-used antipsychotic (~ 200 times more potent as chlorpromazine)
* Triperidol, a highly-potent antipsychotic (100 times more potent than chlorpromazine)
* Melperone, a weakly-potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
* Lenperone
* Domperidone, a dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).

The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.