Quipazine

Drugbox
IUPAC_name = 2-piperazin-1-ylquinoline


width= 240
CAS_number= 4774-24-7
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PubChem= 5011
DrugBank=
C=13 | H=15 | N=3
molecular_weight = 213.278 g/mol
smiles = C1CN(CCN1)C2=NC3=CC=CC=C3C=C2
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Quipazine is a piperazine-based serotonin receptor agonist. It is moderately selective, binding to a range of different serotonin receptors, but particularly to the 5HT_2A [Smith RL, Barrett RJ, Sanders-Bush E. Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor. "Journal of Pharmacology and Experimental Therapeutics". 1995 Nov;275(2):1050-7. PMID 7473132] and 5HT₃ receptors. [Cappelli A, Anzini M, Vomero S, Mennuni L, Makovec F, Doucet E, Hamon M, Bruni G, Romeo MR, Menziani MC, De Benedetti PG, Langer T. Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives. "Journal of Medicinal Chemistry". 1998 Feb 26;41(5):728-41. PMID 9513601]

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