Amodiaquine

Amodiaquine

Systematic (IUPAC) name
4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Half-life	5.2 ± 1.7 (range 0.4 to 5.5) minutes
Identifiers
CAS number	86-42-0 Y
ATC code	P01BA06
PubChem	CID 2165
DrugBank	APRD00796
ChemSpider	2080 Y
UNII	220236ED28 Y
KEGG	D02922 Y
ChEBI	CHEBI:2674 Y
ChEMBL	CHEMBL682 Y
Chemical data
Formula	C20H22ClN3O
Mol. mass	355.861 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) Y Key:OVCDSSHSILBFBN-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Amodiaquine (trade names Camoquin, Flavoquine) is a 4-aminoquinoline compound related to chloroquine, used as an antimalarial and anti-inflammatory agent.

Amodiaquine has been shown to be more effective than chloroquine in treating CRPF (chloroquine-resistant Plasmodium falciparum) malaria infections and may afford more protection than chloroquine when used as weekly prophylaxis. Amodiaquine, like chloroquine, is generally well tolerated. Although licensed, this drug is not marketed in the United States but is widely available in Africa. Its use, therefore, is probably more practicable in long-term visitors and persons who will reside in Africa.^[1]

Amodiaquine is a histamine N-methyltransferase inhibitor.

Notes

1. ^ CDC recommendations for travel to areas with malaria

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Antimalarial agents Quinolines Phenols Organochlorides Antiinfective agent stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Praid Ski jumping at the FIS Nordic World Ski Championships 2007 Look at other dictionaries: amodiaquine hydrochloride — An antimalarial drug, also used in the treatment of amebic hepatitis; large doses may result in sialorrhea, nausea, vomiting, diarrhea, insomnia, palpitations, spasticity, and possibly convulsions. * * * [USP] the dihydrated dihydroch …   Medical dictionary amodiaquine — noun An aminoquinoline compound, related to chloroquine, used as an antimalarial and anti inflammatory agent …   Wiktionary amodiaquine — amo·di·a·quine .am ə dī ə .kwin, .kwēn or amo·di·a·quin .kwin n a compound derived from quinoline and used in the form of its dihydrochloride C20H22ClN3O·2HCl·2H2O as an antimalarial Each boldface word in the list below is a chiefly British… …   Medical dictionary amodiaquine — am·o·di·a·quine …   English syllables amodiaquine — noun see amodiaquin …   Useful english dictionary Амодиахин (Amodiaquine) — противомалярийный лекарственный препарат, сходный по своему влиянию на человеческий организм с хлороквином. Кроме того, данное лекарство применяется для лечения красной волчанки, проказы и ревматоидного артрита. В дозировках, применяемых для… …   Медицинские термины АМОДИАХИН — (amodiaquine) противомалярийный лекарственный препарат, сходный по своему влиянию на человеческий организм с хлороквином. Кроме того, данное лекарство применяется для лечения красной волчанки, проказы и ревматоидного артрита. В дозировках,… …   Толковый словарь по медицине Artemisinin — Systematic (IUPAC) name (3R,5aS,6R,8aS,9R,12S,12aR) octahydro 3,6,9 trimethyl 3,12 epoxy 12H pyrano[4,3 j] 1,2 benzodioxepin 10(3H) one …   Wikipedia Antimalarial drug — Antimalarial drugs are designed to prevent or cure malaria. Some antimalarial agents, particularly chloroquine and hydroxychloroquine, are also used in the treatment of rheumatoid arthritis and lupus associated arthritis. There are many of these… …   Wikipedia Artesunate — drugbox IUPAC name = CAS number = 83507 69 1 CAS supplemental = CAS|80155 81 3 (sodium salt) ATC prefix = P01 ATC suffix = BE03 PubChem = 5464098 DrugBank = C = 19 | H = 28 | O = 8 molecular weight = 384.421 g/mol bioavailability = protein bound …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”