Ebastine

drugbox
IUPAC_name = 4-(4-benzhydryloxy-1-piperidyl)-1-
(4-tert-butylphenyl)butan-1-one

---

CAS_number = 90729-43-4
ATC_prefix = R06
ATC_suffix = AX22
PubChem = 3191
DrugBank =
C = 32 | H = 39 | N = 1 | O = 2
molecular_weight = 469.658 g/mol
bioavailability =
protein_bound = Greater than 95%
metabolism = Hepatic (CYP3A4-mediated), to carebastine
elimination_half-life = 15 to 19 hours (carebastine)
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Oral

Ebastine (trade names Kestine, Evastin, Ebastel, Aleva) is a non-sedating H₁ antihistamine.

It does not penetrate the blood-brain barrier and thus allows an effective block of the H₁ receptor in peripheral tissue without a central side effect, i.e not causing sedation or drowsiness.

The basic patent for ebasine in Europe is EP-B-134124. It is often provided in micronised form, due to poor water solubility.

External links

*cite web | url = http://home.intekom.com/pharm/lennon/kestine.html | title = KESTINE Package Insert | date = 1997-10-24 | accessdate = 2007-04-01 | publisher = South African Electronic Package Inserts