Alfuzosin

Alfuzosin

drugbox
IUPAC_name = "N"- [3- [(4-amino-6,7-dimethoxy-quinazolin-2-yl)- methyl-amino] propyl] tetrahydrofuran- 2-carboxamide


CAS_number = 81403-80-7
ATC_prefix = G04
ATC_suffix = CA01
PubChem = 2092
ChemSpiderID = 2008
DrugBank = APRD00490
C = 19 | H = 27 | N = 5 | O = 4
molecular_weight = 389.449 g/mol
bioavailability = 49%
protein_bound = 82%-90%
metabolism = Hepatic (CYP3A4-mediated)
elimination_half-life = 10 hours
excretion = Fecal (69%) and renal (24%)
pregnancy_AU = B2
pregnancy_US = B
legal_UK = POM
legal_US = Rx-only
routes_of_administration = Oral

Alfuzosin (INN, provided as the hydrochloride salt) is an α1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.

Alfuzosin is marketed in the United States by Sanofi Aventis under the brand name Uroxatral and elsewhere under the tradename Xatral. Alfuzosin was approved by the FDA for treatment of BPH in June 2003.

Side effects

The most common side effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, and fatigue.

Contraindications

Alfuzosin should be used with caution in patients with severe renal insufficiency, and should not be prescribed to patients with a known history of QT prolongation who are taking medications known to prolong the QT interval.


External links

* [http://www.uroxatral.com/ Uroxatral] (manufacturer's website)
* [http://www.meds-help.com/alfuzosin/ Alfuzosin] (patient information)


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