Aceclidine

Drugbox
IUPAC_name = 1-azabicyclo [2.2.2] oct-8-yl acetate

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CAS_number=827-61-2
ChemSpiderID = 1902
CAS_supplemental=(or 6109-70-2 [HCl] )
ATC_prefix=S01
ATC_suffix=EB08
ATC_supplemental=
PubChem=1979
DrugBank=
C = 9 | H = 15 | N = 1 | O = 2
molecular_weight = 169.221 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status = Rx-only
routes_of_administration= Ocular

Aceclidine (INN) (trade names Glaucostat, Glaunorm, Glaudin) is a parasympathomimetic miotic agent used in the treatment of narrow angle glaucoma. It decreases intraocular pressure.

Mechanism of action

Aceclidine acts primarily on the muscarinic receptor.cite journal |author=Shannon HE, Hart JC, Bymaster FP, "et al" |title=Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats |journal=J. Pharmacol. Exp. Ther. |volume=290 |issue=2 |pages=901–7 |year=1999 |month=August |pmid=10411607 |doi= |url=http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=10411607]

ide effects

Side effects of aceclidine include increased salivation, bradycardia (in excessive doses).

References

* [http://www.biam2.org/www/Sub2841.html ACECLIDINE CHLORHYDRATE] [Article in French] "Biam". Last update: 2 September 1999. Accessed 13 September 2005 (UTC)
* [http://www.vidal.ru/vidal/info/acts/a_5.htm ACECLIDINE (АЦЕКЛИДИН)] [Article in Russian] ViDAL 2005. Accessed 13 September 2005.