COMT inhibitor

COMT inhibitor

A COMT inhibitor is an enzyme which inhibits the action of catechol-O-methyl transferase. This enzyme is involved in degrading neurotransmitters.

COMT inhibitors are used in the treatment of Parkinson's disease.

An example is entacapone.cite journal |author=Nissinen E, Nissinen H, Larjonmaa H, "et al" |title=The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats |journal=J Neural Transm |volume=112 |issue=9 |pages=1213–21 |year=2005 |month=September |pmid=15614425 |doi=10.1007/s00702-004-0262-4 |url=http://dx.doi.org/10.1007/s00702-004-0262-4]

Another example is tolcapone.cite journal |author=Giakoumaki SG, Roussos P, Bitsios P |title=Improvement of Prepulse Inhibition and Executive Function by the COMT Inhibitor Tolcapone Depends on COMT Val158Met Polymorphism |journal=Neuropsychopharmacology |volume= |issue= |pages= |year=2008 |month=June |pmid=18536698 |doi=10.1038/npp.2008.82 |url=http://dx.doi.org/10.1038/npp.2008.82]

References


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