Pargyline

drugbox
IUPAC_name = "N"-Benzyl-"N"-methyl-prop-2-yn-1-amine


CAS_number = 555-57-7
ATC_prefix = C02
ATC_suffix = KC01
ATC_supplemental = ATC|C02|LL01
PubChem = 4688
DrugBank =
C = 11 | H = 13 | N = 1
molecular_weight = 159.23 g/mol
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Pargyline is a monoamine oxidase B (MAO-B) inhibitor. cite journal |author=Murphy DL, Karoum F, Pickar D, "et al" |title=Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline) |journal=J. Neural Transm. Suppl. |volume=52 |issue= |pages=39–48 |year=1998 |pmid=9564606 |doi= |url=]

It has antihypertensive effects.cite journal |author=Fuentes JA, Ordaz A, Neff NH |title=Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats |journal=Eur. J. Pharmacol. |volume=57 |issue=1 |pages=21–7 |year=1979 |month=July |pmid=477738 |doi= |url=]

Pharmacology

It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis. [Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006]

References