- Sotalol
drugbox
IUPAC_name = "N"- [4-(1-hydroxy-2-isopropylamino-
ethyl)-phenyl] -methanesulfonamide
CAS_number = 3930-20-9
ATC_prefix=C07
ATC_suffix=AA07
PubChem=5253
DrugBank=
C=12 | H=20 | N=2 | O=3 | S=1
molecular_weight = 272.3624 g/mol
bioavailability = >95%
metabolism = Not metabolised
elimination_half-life = 12 hours
excretion = Renal
Lactic (In lactating females)
pregnancy_AU =
pregnancy_US = B
pregnancy_category =
legal_status = Rx-only
routes_of_administration = oralSotalol (trade names Betapace and Betapace AF,
Berlex Laboratories , Sotalex and Sotacor,Bristol-Myers Squibb ) is a drug used in individuals with rhythm disturbances (cardiac arrhythmia s) of theheart , and to treat hypertension in some individuals.Pharmacology
It falls into the class III
antiarrhythmic agents because it inhibits thepotassium ion channel s in the heart. It is also abeta blocker because of its action on the β-adrenergic receptor s in the heart.cite journal |author=Kulmatycki KM, Abouchehade K, Sattari S, Jamali F |title=Drug-disease interactions: reduced beta-adrenergic and potassium channel antagonist activities of sotalol in the presence of acute and chronic inflammatory conditions in the rat |journal=Br. J. Pharmacol. |volume=133 |issue=2 |pages=286–94 |year=2001 |month=May |pmid=11350865 |pmc=1572777 |doi=10.1038/sj.bjp.0704067 |url=http://dx.doi.org/10.1038/sj.bjp.0704067]By blocking the potassium channels, sotalol prolongs
repolarization , therefore lengthening theQT interval and decreasing automaticity.It also slows atrioventricular (AV) nodal conduction (beta-blocking effect).
Sotalol is a
racemic mix of D and Lenantiomers . The L isomer is a beta blocker.Sotalol is not selected for its beta-blocking ability, but rather for its Class III (potassium blocking) properties.
Indications
Some evidence suggests that sotalol should be avoided in the setting of decreased
ejection fraction due to heart attack. [cite journal | author = Waldo A, Camm A, deRuyter H, Friedman P, MacNeil D, Pauls J, Pitt B, Pratt C, Schwartz P, Veltri E | title = Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol | journal = Lancet | volume = 348 | issue = 9019 | pages = 7–12 | year = 1996 | pmid = 8691967 | doi = 10.1016/S0140-6736(96)02149-6]It has also been suggested that it be used in the prevention of atrial fibrillation.cite journal |author=Patel A, Dunning J |title=Is Sotalol more effective than standard beta-blockers for the prophylaxis of atrial fibrillation during cardiac surgery |journal=Interact Cardiovasc Thorac Surg |volume=4 |issue=2 |pages=147–50 |year=2005 |month=April |pmid=17670378 |doi=10.1510/icvts.2004.102152 |url=http://icvts.ctsnetjournals.org/cgi/pmidlookup?view=long&pmid=17670378]
References
ee also
*
Antiarrhythmic agents
*Beta blocker
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