Setoperone

Setoperone is a compound that is a ligand to the 5-HT_2A receptor. It can be radiolabeled with the radioisotope fluorine-18 and used as a radioligand with positron emission tomography (PET).Several research studies have used the radiolabeled setoperone in neuroimaging for the studying neuropsychiatric disorders, such as depression [Cite journal
author = Jeffrey H. Meyer, Shitij Kapur, Sylvain Houle, Jean DaSilva, Beata Owczarek, Gregory M. Brown, Alan A. Wilson and Sidney H. Kennedy
title = Prefrontal Cortex 5-HT2 Receptors in Depression: An ¹⁸FSetoperone PET Imaging Study
journal = American Journal of Psychiatry
volume = 156
pages = 1029–1034
month = July
year = 1999
url = http://ajp.psychiatryonline.org/cgi/content/full/156/7/1029] or schizophrenia. [Cite journal
author = Ralph Lewis, Shitij Kapur, Corey Jones, Jean DaSilva, Gregory M. Brown, Alan A. Wilson, Sylvain Houle and Robert B. Zipursky
title = Serotonin 5-HT₂ Receptors in Schizophrenia: A PET Study Using ¹⁸FSetoperone in Neuroleptic-Naive Patients and Normal Subjects
journal = American Journal of Psychiatry
volume = 156
pages = 72–78
month = January
year = 1999
url = http://ajp.psychiatryonline.org/cgi/content/abstract/156/1/72]

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