- Flibanserin
Drugbox
IUPAC_name = 1- [2- [4-(3-trifluoromethyl phenyl) piperazin-1-yl] ethyl] benzimidazol- [1H] -2-one
CAS_number=167933-07-5
C=20 | H=21 | F=3 | N=4 | O=1
molecular_weight = 390.40 g/molFlibanserin [cite journal | author = Borsini F, Evans K, Jason K, Rohde F, Alexander B, Pollentier S| url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12177684&dopt=Abstract|title = Pharmacology of flibanserin | journal = CNS Drug Rev.| volume = 8| issue = 2| pages = 117–142| year = 2002| month=summer] is a drug produced by
Boehringer Ingelheim . It is currently being investigated as a drug for women suffering from decreased sexual desire. It is a 5-HT1Aserotonin receptor agonist and 5-HT2a serotonin receptor antagonist that had initially been developed as an anti-depressant. [cite journal|author = Invernizzi RW, Sacchetti G, Parini S, Acconcia S, Samanin R | url=http://www.nature.com/bjp/journal/v139/n7/full/0705341a.html | title= Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors. | journal= Br J Pharmacol.| volume=139| issue=7| pages= 1281–8| year= 2003 | month= Aug | doi= 10.1038/sj.bjp.0705341]References
External links
* [http://www.businessweek.com/bwdaily/dnflash/content/dec2006/db20061228_315249.htm Viagra for women?] .
* [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12135537&dopt=Abstract Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain]
* [http://www.nature.com/bjp/journal/v130/n4/full/0703364a.html Flibanserin has anxiolytic effects without locomotor side effects in the infant rat ultrasonic vocalization model of anxiety]
* [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=10647099&dopt=Abstract Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brain]
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