Pirenzepine

Pirenzepine (marketed by Boehringer Ingelheim under the trade-name Gastrozepin) is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), the result being an increase in gastric motility and digestion. It has no effects on the brain and spinal cord as it cannot diffuse through the blood-brain barrier.

Pirenzepine has been investigated for use in myopia control. [cite journal | author = Czepita D | title = Fundamentals of modern treatment of myopia | journal = Ann Acad Med Stetin | volume = 51 | issue = 2 | pages = 5–9 | year = 2005 | pmid = 16519089]

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