Edrophonium

Edrophonium

drugbox
IUPAC_name = ethyl-(3-hydroxyphenyl)-dimethyl-ammonium



width = 200
CAS_number = 116-38-1
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PubChem = 3202
DrugBank = APRD00944
C=10 | H=16 | N=1 | O=1 | charge=+
molecular_weight = 166.24 g/mol
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Edrophonium is a readily reversible acetylcholinesterase inhibitor. It prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction. It is sold under the trade names Tensilon, Enlon and Reversol.

Clinical uses

Because its duration of action is only about 20 minutes, edrophonium (by the so-called Tensilon test) is used to differentiate myasthenic crisis from cholinergic crisis. In myasthenic crisis, where a person is not able to produce enough neuromuscular stimulation, edrophonium will reduce the muscle weakness by effectively supplying more acetylcholine. In a cholinergic crisis, where a person has too much neuromuscular stimulation, edrophonium will make the muscle weakness worse by inducing a depolarizing block.

ources

#Brenner, G. M. (2000). "Pharmacology." Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
#Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4


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Look at other dictionaries:

  • edrophonium — ed·ro·pho·ni·um .ed rə fō nē əm n an anticholinesterase C10H16ClNO used esp. to stimulate skeletal muscle and in the diagnosis of myasthenia gravis called also edrophonium chloride see TENSILON * * * n. an anticholinesterase drug that is… …   Medical dictionary

  • edrophonium — ˌedrəˈfōnēəm noun ( s) Etymology: ethyl + hydroxy + phenyl + ammonium : an anticholinesterase C10H16ClNO used especially to stimulate skeletal muscle and in the diagnosis of myasthenia gravis called also edrophonium chloride * * * …   Useful english dictionary

  • edrophonium chloride — noun see edrophonium …   Useful english dictionary

  • edrophonium — /ed reuh foh nee euhm/, n. Pharm. a substance, C10H16BrNO, used to reverse certain muscle relaxing agents, such as tubocurarine, in surgical procedures: also used in the diagnosis of myasthenia gravis. [contr. of components of the chemical name]… …   Universalium

  • edrophonium — edro·pho·nium …   English syllables

  • edrophonium — n. an anticholinesterase drug that is used after surgery to reverse the effects of nondepolarizing muscle relaxants and in a test for diagnosis of myasthenia gravis. It is administered by injection; side effects can include nausea and vomiting,… …   The new mediacal dictionary

  • edrophonium chloride — A short duration competitive antagonist of skeletal muscle relaxants (curare derivatives and gallamine triethiodide) and an anticholinesterase, used as an antidote for curariform drugs, as a diagnostic agent in myasthenia gravis, and in …   Medical dictionary

  • Эдрофониум (Edrophonium) — лекарственное вещество, стимулирующее активность скелетных мышц (см. Парасимпатомиметическое лекарственное вещество). Назначается в инъекциях для уточнения диагноза тяжелой псевдопаралитической миастении. Возможные побочные эффекты: тошнота,… …   Медицинские термины

  • Tensilon — Edrophonium Général Nom IUPAC éthyl (3 hydroxyphényl) diméthylammonium Synonymes édrophoni …   Wikipédia en Français

  • Myasthenia gravis — Classification and external resources Detailed view of a neuromuscular junction: 1. Axon 2. Sarcolemma 3. Synaptic vesicle 4. Nicotinic acetylcholine receptor 5. Mitochondrion …   Wikipedia

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