Etanautine

drugbox
IUPAC_name = 2- [di(phenyl)methoxy] -N,N-dimethylethanamine; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid

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CAS_number = 88637-37-0
ATC_prefix = N04
ATC_suffix = AB01
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DrugBank =
C=26|H=31|N=5|O=5
molecular_weight = 493.555 g/mol
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Etanautine (or diphenhydramine monoacefyllinate) is a anticholinergic used as an anti-parkinson drug. It is a 1:1 salt of diphenhydramine with acefylline, similar to the diphenydramine/8-chlorotheophylline combination product dimenhydrinate.

As with dimenhydrinate, the stimulant effect of the acefylline counteracts the sedative effect from the diphenhydramine, resulting in an improved therapeutic profile.

The 1:2 salt diphenhydramine diacefylline (with two molecules of acefylline to each molecule of diphenhydramine) is also used in medicine, under the brand name Nautamine.