Himbacine

Drugbox
IUPAC_name = (1S,3aS,4aR,8aS,9R,9aR)-9- [(E)-2- [(2R,6S)-1,6-dimethylpiperidin-2-yl] ethenyl] -1-methyl-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-1H-naphtho [3,2-c] furan-3-one

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CAS_number = 6879-74-9
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PubChem = 6436265
DrugBank =
C=22|H=35|N=1|O=2
molecular_weight = 345.27
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Himbacine is an alkaloid isolated from the bark of Australian magnolias. Himbacine has been synthesized using a Diels-Alder reaction as a key step.cite journal |author=Chackalamannil S, Davies RJ, Wang Y, "et al" |title=Total Synthesis of (+)-Himbacine and (+)-Himbeline |journal=J. Org. Chem. |volume=64 |issue=6 |pages=1932–1940 |year=1999 |month=March |pmid=11674285 |doi= |url=http://dx.doi.org/10.1021/jo981983+] Himbacine's activity as a muscarinic receptor antagonist made it a promising starting point in Alzheimer's disease research. The development of a muscarinic antagonist based on Himbacine failed but an analog is now in clinical trials as a thrombin antagonist.cite web |url=http://pipeline.corante.com/archives/2008/05/13/in_which_i_hate_a_wonder_drug.php |title=Blog entry about Himbacine and its history in drug development |format= |work= |accessdate=]

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