Benperidol

drugbox
IUPAC_name = 1-(1-(4-(4-fluorophenyl)-4- oxobutyl)piperidin-4-yl)-1"H"- benzo ["d"] imidazol-2(3"H")-one

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width = 250
CAS_number = 983-42-6
ATC_prefix = N05
ATC_suffix = AD07
PubChem = 16363
DrugBank =
C=22 | H=24 | F=1 | N=3 | O=2
molecular_weight = 381.443g/mol
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legal_US = Rx-only
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routes_of_administration = Oral

Benperidol is a drug which is a highly potent butyrophenone derivative. It is in fact the most potent neuroleptic on the european market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol). [Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)] . It is an antipsychotic, which can be used for the treatment of schizophrenia [ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.] , but it is primarily used to control deviant, antisocial hypersexual behaviour [British National Formulary (49th), British Medical Association 2005 p 183] , and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone. [Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.]

Benperidol was discovered at Janssen Pharmaceutica in 1961.

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