Raclopride

Raclopride

drugbox
IUPAC_name = 3,5-dichloro-"N"- [(1-ethylpyrrolidin-2-yl)methyl] -
2-hydroxy-6-methoxy-benzamide


CAS_number = 84225-95-6
ATC_prefix =
ATC_suffix =
PubChem = 3033769
DrugBank =
C=15|H=20|Cl=2|N=2|O=3
molecular_weight = 347.236 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life = 30 min
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration =

Raclopride is a synthetic compound that acts as an antagonist on D2 dopamine receptors. [Cite journal
author = C. Kohler, H. Hall, S. O. Ogren & L. Gawell
title = Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain
journal = Biochemical Pharmacology
volume = 34
issue = 13
pages = 2251–2259
year = 1985
month = July
pmid = 4015674] It can thus be used as a neuroleptic agent to treat schizophrenia. It can be radiolabelled with the carbon-11 radioisotope and used in positron emission tomography (PET) scanning to assess the degree of dopamine binding to the D2 neuroreceptor.For example, one study found decreasing binding with the personality trait "detachment". [Cite journal
author = Lars Farde, J. Petter Gustavsson & Erik Jönsson
title = D2 dopamine receptors and personality traits
journal = Nature
volume = 385
issue = 6617
pages = 590
year = 1997
month = February
doi = 10.1038/385590a0
pmid = 9024656]

References


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