IUPAC_name = (6a"R",9"R",10a"R")-9-(methylthiomethyl)-7-propyl--4,6,6a,7,8,9,10,10a-octahydroindolo [4,3-"fg"] quinoline

width = 180
CAS_number = 66104-22-1
ATC_prefix = N04
ATC_suffix = BC02
ATC_supplemental =
PubChem = 47811
DrugBank = APRD00663
C = 19 | H = 26 | N = 2 | S = 1
molecular_weight = 314.489 g/mol
bioavailability =
protein_bound = 90%
metabolism = Extensively hepatic
elimination_half-life = 27 hours
pregnancy_category = B
legal_status = Withdrawn (U.S.)
routes_of_administration = Oral

Pergolide is an ergoline-based dopamine receptor agonist used for the treatment of Parkinson's disease.

Parkinson's disease is associated with low levels of the neurotransmitter dopamine in the brain. Pergolide has some of the same effects as dopamine in the body.


Pergolide is also used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease, although it has also been used to treat discomfort or pain in the lower extremities that can only be relieved by moving the legs. Pergolide is often used in conjunction with other medicines in the treatment of Parkinson's disease. Since Pergolide can reduce prolactin levels, it is often used to treat hyperprolactinemia.

Furthermore, pergolide may also be used for veterinary purposes. It is commonly used for the treatment of pituitary pars intermedia hyperplasia or Equine Cushing's Syndrome (ECS) in horses. [cite web |url= |title=Pergolide For Veterinary Use |author=Barbara Forney, VMD ]

ide effects

The drug is in decreasing use, as it was reported in 2003 to be associated with a form of heart disease called cardiac fibrosis. [cite journal | url = | year = 2004 | month = August | title = Cardiac valvulopathy with pergolide | author = ADRAC | journal = Aust Adv Drug React Bull | volume = 23 | issue = 4 [ Free full text] from the Australian Therapeutic Goods Administration] This problem is thought to be due to pergolide's action at the 5-HT2B serotonin receptors of cardiac myocytes, causing proliferative valve disease by the same mechanism as ergotamine, methysergide, fenfluramine, and other serotonin 5-HT2B agonists, including serotonin itself when elevated in the blood in carcinoid syndrome. Pergolide can rarely cause Raynaud's phenomenon. Among similar antiparkinsonian drugs, cabergoline but not lisuride exhibit this same type of serotonin receptor binding. [ Jähnichen S, Horowski R, Pertz H. PDFlink| [ "Pergolide and Cabergoline But not Lisuride Exhibit Agonist Efficacy at Serotonin 5-HT2B Receptors".] |515 KiB Presentation. Retrieved on 2007-03-30.] In January, 2007, cabergoline (Dostinex) was reported also to be associated with valvular proliferation heart damage. [cite journal |author=Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E |title=Dopamine agonists and the risk of cardiac-valve regurgitation |journal=N Engl J Med |volume=356 |issue=1 |pages=29–38 |year=2007 |pmid=17202453 |doi=10.1056/NEJMoa062222] In March 2007, pergolide was withdrawn from the U.S. market due to serious valvular damage that was shown in two independent studies.cite web | url = | title = MedWatch - 2007 Safety Information Alerts. Permax (pergolide) and generic equivalents | publisher = U.S. Food and Drug Administration | date = March 29, 2007 | accessdate = 2007-03-30]

Pergolide has also been shown to impair associative learning. [cite journal |author=Breitenstein C "et al". |title=Tonic dopaminergic stimulation impairs associative learning in healthy subjects |journal=Neuropsychopharmacology |volume=31 |issue=11 |pages=2552–64 |year=2006 |pmid=16880771 |doi=10.1038/sj.npp.1301167]

On March 30th, 2007, manufacturers of Pergolide agreed to withdraw the drug from the U.S. market after several published studies revealed a link between the drug and increased rates of valvular dysfunction. [ [ Pergolide Withdrawn From US Market] ] However, Pergolide is still available in many other countries including Canada.


Wikimedia Foundation. 2010.

Нужна курсовая?

Look at other dictionaries:

  • pergolide — noun A dopamine receptor agonist used for the treatment of Parkinsons disease …   Wiktionary

  • pergolide — per·go·lide pər gə .līd n an agonist of dopamine receptors that is an ergot derivative and is used in the form of its mesylate C19H26N2S·CH4O3S esp. in the treatment of Parkinson s disease * * * n. a drug that stimulates dopamine receptors in the …   Medical dictionary

  • pergolide — n. a drug that stimulates dopamine receptors in the brain and is used in the treatment of Parkinson s disease. It is administered by mouth. Possible side effects include confusion, hallucinations, sleepiness, heart irregularity, nausea, breathing …   The new mediacal dictionary

  • pergolide mesylate — An ergot derivative with dopaminergic properties; used in parkinsonism. * * * per·go·lide mes·y·late (purґgo līd″) a long acting ergot derivative with dopaminergic properties, formerly used as an adjunct in the treatment of… …   Medical dictionary

  • Перголид (Pergolide) — лекарственное вещество, которое оказывает стимулирующее действие на находящиеся в головном мозге рецепторы дофамина; применяется для лечения паркинсонизма. Назначается внутрь. Возможные побочные эффекты: спутанность сознания, галлюцинации,… …   Медицинские термины

  • ПЕРГОЛИД — (pergolide) лекарственное вещество, которое оказывает стимулирующее действие на находящиеся в головном мозге рецепторы дофамина; применяется для лечения паркинсонизма. Назначается внутрь. Возможные побочные эффекты: спутанность сознания,… …   Толковый словарь по медицине

  • Serotonin — chembox ImageFileL1 = Serotonin (5 HT).svg ImageSizeL1 = 145px ImageFileR1 = Serotonin 3D vdW.png ImageSizeR1 = 145px IUPACName = 5 Hydroxytryptamine or 3 (2 aminoethyl) 1 H indol 5 ol OtherNames = Section1 = Chembox Identifiers CASNo = 50 67 9… …   Wikipedia

  • Cabergoline — Systematic (IUPAC) name N [3 (Dimethylamino)propyl] N [(ethylamino)carbonyl] 6 (2 propenyl) 8g ergoline 8 carboxamide or 1 [(6 allylergolin8β yl) carbonyl] 1 [3 (dimethylamino)propyl] 3 ethylurea …   Wikipedia

  • Cardiac fibrosis — refers to an abnormal thickening of the heart valves due to inappropriate proliferation of cardiac fibroblasts. Fibrocyte cells normally secrete collagen, and function to provide structural support for the heart. When over activated this process… …   Wikipedia

  • Lisuride — Systematic (IUPAC) name 1,1 diethyl 3 ((6aR,9S) 7 methyl Clinical data AHFS/ …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”