Manidipine

Manidipine
Manidipine
Systematic (IUPAC) name
2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status ℞ Prescription only
Identifiers
CAS number 89226-50-6 120092-68-4
ATC code C08CA11
PubChem CID 4008
ChemSpider 3868
UNII 6O4754US88 YesY
Chemical data
Formula C35H38N4O6 
Mol. mass 610.69 g/mol
SMILES eMolecules & PubChem

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive[1][2][3][4][5]

Currently Manidipine is marketed by:

-Greek Pharmaceutical group Chiesi Hellas under the brands Manyper, Artedil, Manivasc and Iperten (formerly sold by Torrex Pharma GmbH, now owned by Chiesi Hellas), in Germany, Greece, France, Austria, Spain, Italy and Brazil.

-Takeda Chemical Industries, under the brands Vascoman, Calslot, and Madiplot, in Italy, Japan, Philippines and Thailand.

References

  1. ^ Cheer, S.M.; McClellan, K. (2001), "Manidipine: A Review of its Use in Hypertension", Drugs 61 (12): 1777, PMID 11693466, http://drugs.adisonline.com/pt/re/drugs/abstract.00003495-200161120-00010.htm, retrieved 2009-06-20 
  2. ^ McKeage, K.; Scott, L.J. (2004), "Manidipine: A Review of its Use in the Management of Hypertension", Drugs 64 (17): 1923, PMID 15329044, http://drugs.adisonline.com/pt/re/drugs/abstract.00003495-200464170-00011.htm, retrieved 2009-06-20 
  3. ^ Roca-cusachs, A.; Triposkiadis, F. (2005), "Antihypertensive Effect of Manidipine", Drugs 65: 11, PMID 16398058, http://drugs.adisonline.com/pt/re/drugs/abstract.00003495-200565002-00003.htm, retrieved 2009-06-20 
  4. ^ Otero, M.L. (2007), "Manidipine-delapril combination in the management of hypertension", Vascular Health and Risk Management 3 (3): 255, PMC 2293964, PMID 17703633, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2293964, retrieved 2009-06-20 
  5. ^ Mizuno, Kenji; Hiroshi Haga, Michihiko Takahashi, Soitsu Fukuchi (1992-08), "Evaluation of manidipine hydrochloride, a new calcium antagonist, in the treatment of hypertensive patients with renal disorders", Current Therapeutic Research 52 (2): 248–253, doi:10.1016/S0011-393X(05)80475-8, http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS8-4GHBHXV-5&_user=10&_coverDate=08%2F31%2F1992&_rdoc=5&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236256%231992%23999479997%23600363%23FLP%23display%23Volume)&_cdi=6256&_sort=d&_docanchor=&_ct=16&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4a139e549c7d88da59d7ebdfe6f44be7, retrieved 2009-06-20 
v · d · eChannel blocker: calcium channel blockers (C08)
Selective
Dihydropyridines ("-dipine")
Amlodipine# • Aranidipine • Azelnidipine • Barnidipine • Benidipine • Cilnidipine • Clevidipine • Darodipine • Efonidipine • Felodipine • Isradipine • Lacidipine • Manidipine • Lercanidipine • Mepirodipine • Nicardipine • Nifedipine# • Niludipin • Nilvadipine • Nimodipine • Nisoldipine • Nitrendipine • Oxodipine • Pranidipine • Ryodipine
Phenylalkylamines ("-pamil")
Anipamil  • Devapamil • Emopamil • Falipamil  • Gallopamil • Norverapamil  • Verapamil
1-4 Benzothiazepines ("-tiazem")
Non-selective
Bepridil • Fendiline • Lidoflazine • Perhexiline
Other/ungrouped
Amrinone  • Anandamide  • Azimilide  • Bencyclane  • Berbamine  • Bevantolol • Canadine • Carboxyamidotriazole  • Caroverine  • Cinnarizine  • Conotoxins  • Dauricine  • Dimeditiapramine • Dotarizine • Enpiperate  • Eperisone • Fantofarone  • Fasudil  • Fenamic acid  • Flunarizine  • Fostedil • Gabapentin  • Lamotrigine  • Magnesium sulfate  • Manoalide • Mibefradil‡  • Monatepil  • Naftopidil  • Niguldipine  • Ochratoxin A • Octylonium  • Osthol  • Pinaverium  • Piperidine  • Pregabalin  • Prenylamine  • Risedronic acid • Sesamodil  • Stepholidine  • Terodiline  • Tetrahydropalmatine  • Tetrandrine  • Tolfenamic acid • Tranilast  • TROX-1  • Ziconotide
#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III

M: VAS

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noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)


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