Isradipine

Isradipine
Isradipine
Systematic (IUPAC) name
3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a693048
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Protein binding 95%
Half-life 8 hours
Identifiers
CAS number 75695-93-1
ATC code C08CA03
PubChem CID 3784
DrugBank APRD00298
ChemSpider 3652 YesY
UNII YO1UK1S598 YesY
KEGG D00349 YesY
ChEMBL CHEMBL1648 YesY
Chemical data
Formula C19H21N3O5 
Mol. mass 371.387 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. More recent research in animal models suggests that isradipine may have potential uses for treating Parkinson's disease Chan et al. 2007.

Further reading

  • Hattori T, Wang P (2006). "Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts.". Eur J Med Res 11 (3): 93–6. PMID 16751108. 
  • Ganz M, Mokabberi R, Sica D (2005). "Comparison of blood pressure control with amlodipine and controlled-release isradipine: an open-label, drug substitution study.". J Clin Hypertens (Greenwich) 7 (4 Suppl 1): 27–31. doi:10.1111/j.1524-6175.2005.04450.x. PMID 15858400. 
  • Johnson B, Roache J, Ait-Daoud N, Wallace C, Wells L, Dawes M, Wang Y (2005). "Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effects.". Int J Neuropsychopharmacol 8 (2): 203–13. doi:10.1017/S1461145704005036. PMID 15850499. 
  • Fletcher H, Roberts G, Mullings A, Forrester T (1999). "An open trial comparing isradipine with hydralazine and methyl dopa in the treatment of patients with severe pre-eclampsia.". J Obstet Gynaecol 19 (3): 235–8. doi:10.1080/01443619964977. PMID 15512286. 
  • Chan CS, Guzman JN, Ilijic E, Mercer JN, Rick C, Tkatch T, Meredith GE, Surmeier DJ (2007). "'Rejuvenation' protects neurons in mouse models of Parkinson's disease.". Nature 447 (3): 1081–1086. doi:10.1038/nature05865. PMID 17558391. 

External links

v · d · eChannel blocker: calcium channel blockers (C08)
Selective
Dihydropyridines ("-dipine")
Amlodipine# • Aranidipine • Azelnidipine • Barnidipine • Benidipine • Cilnidipine • Clevidipine • Darodipine • Efonidipine • Felodipine • Isradipine • Lacidipine • Manidipine • Lercanidipine • Mepirodipine • Nicardipine • Nifedipine# • Niludipin • Nilvadipine • Nimodipine • Nisoldipine • Nitrendipine • Oxodipine • Pranidipine • Ryodipine
Phenylalkylamines ("-pamil")
Anipamil  • Devapamil • Emopamil • Falipamil  • Gallopamil • Norverapamil  • Verapamil
1-4 Benzothiazepines ("-tiazem")
Non-selective
Bepridil • Fendiline • Lidoflazine • Perhexiline
Other/ungrouped
Amrinone  • Anandamide  • Azimilide  • Bencyclane  • Berbamine  • Bevantolol • Canadine • Carboxyamidotriazole  • Caroverine  • Cinnarizine  • Conotoxins  • Dauricine  • Dimeditiapramine • Dotarizine • Enpiperate  • Eperisone • Fantofarone  • Fasudil  • Fenamic acid  • Flunarizine  • Fostedil • Gabapentin  • Lamotrigine  • Magnesium sulfate  • Manoalide • Mibefradil‡  • Monatepil  • Naftopidil  • Niguldipine  • Ochratoxin A • Octylonium  • Osthol  • Pinaverium  • Piperidine  • Pregabalin  • Prenylamine  • Risedronic acid • Sesamodil  • Stepholidine  • Terodiline  • Tetrahydropalmatine  • Tetrandrine  • Tolfenamic acid • Tranilast  • TROX-1  • Ziconotide

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)

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Look at other dictionaries:

  • Isradipine — Général No CAS …   Wikipédia en Français

  • isradipine — is·rad·i·pine (is radґĭ pēn) [USP] a calcium channel blocking agent with actions similar to those of nifedipine, used alone or with a thiazide diuretic for the treatment of hypertension; administered orally …   Medical dictionary

  • 75695-93-1 — Isradipine Isradipine Général No CAS …   Wikipédia en Français

  • C19H21N3O5 — Isradipine Isradipine Général No CAS …   Wikipédia en Français

  • Dihydropyridine — Systematic name 1,4 Dihydropyridine[1] …   Wikipedia

  • Calcium channel blocker — A calcium channel blocker (CCB) is a chemical that disrupts the movement of calcium (Ca2+) through calcium channels.[1] CCB drugs devised to target neurons are used as antiepileptics. However, the most widespread clinical usage of calcium channel …   Wikipedia

  • 3337-17-5 — Dihydropyridine Dihydropyridine Général Nom IUPAC 1,4 dyhydroazine Synonymes …   Wikipédia en Français

  • Antagoniste Du Calcium — Bloqueurs de canaux calciques Les antagonistes du calcium freinent l entrée du calcium dans les cellules, surtout au niveau du système cardio vasculaire, mais les différentes classes exercent toutefois des effets sensiblement différents.… …   Wikipédia en Français

  • Antagoniste du calcium — Bloqueurs de canaux calciques Les antagonistes du calcium freinent l entrée du calcium dans les cellules, surtout au niveau du système cardio vasculaire, mais les différentes classes exercent toutefois des effets sensiblement différents.… …   Wikipédia en Français

  • Bloqueurs de canaux calciques — Les antagonistes du calcium freinent l entrée du calcium dans les cellules, surtout au niveau du système cardio vasculaire, mais les différentes classes exercent toutefois des effets sensiblement différents. Phénylalcylamines Gallopamil Le… …   Wikipédia en Français

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