Azelnidipine

Drugbox
IUPAC_name = O3- [1- [di(phenyl)methyl] azetidin-3-yl] O5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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CAS_number = 123524-52-7
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PubChem = 65948
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chemical_formula =
C=33 | H=34 | N=4 | O=6
molecular_weight = 582.64 g/mol
smiles = CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5) [N+] (=O) [O-] )C(=O)OC(C)C
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legal_status = Rx-only
routes_of_administration = Oral

Azelnidipine (INN; marketed under the brand name Calblock) is a dihydropyridine calcium channel blocker.

Unlike nicardipine, it has a gradual onset and has a long-lasting hypotensive effect, with little increase in heart rate.cite journal |author=Oizumi K, Nishino H, Koike H, Sada T, Miyamoto M, Kimura T |title=Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker |journal=Jpn. J. Pharmacol. |volume=51 |issue=1 |pages=57–64 |year=1989 |month=September |pmid=2810942 |doi= |url=http://joi.jlc.jst.go.jp/JST.Journalarchive/jphs1951/51.57?from=PubMed]

References