Nicardipine

Nicardipine

Systematic (IUPAC) name
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a695032
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	>95%
Half-life	8.6 hours
Identifiers
CAS number	55985-32-5
ATC code	C08CA04
PubChem	CID 4474
DrugBank	APRD00088
ChemSpider	4319 Y
UNII	CZ5312222S Y
KEGG	D08270 Y
ChEMBL	CHEMBL1484 Y
Chemical data
Formula	C26H29N3O6
Mol. mass	479.525 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3 Y Key:ZBBHBTPTTSWHBA-UHFFFAOYSA-N Y
Physical data
Melt. point	136-138 °C °C (Expression error: Unrecognised punctuation character "�" °F)
Y(what is this?)  (verify)

Nicardipine hydrochloride (Cardene) is a medication used to treat high blood pressure and angina. It belongs to the class of calcium channel blockers.

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hypertension, and Raynaud's phenomenon. It is available in oral and intravenous formulations. Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridines (amlodipine, felodipine), except that nicardipine is more selective for cerebral and coronary blood vessels. Furthermore, nicardipine does not intrinsically decrease myocardial contractility and may be useful in the management of congestive heart failure. Nicardipine also has a longer half-life than nifedipine. Nicardipine was approved by the FDA in December 1988. The patent for both Cardene and Cardene SR expired in October 1995.

It has been used in percutaneous coronary intervention.^[1]

Nicardipine must be used with caution in patients with renal failure because of possible kidney shutdown.

Nicardipine inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. The effects of nicardipine are more selective to vascular smooth muscle than cardiac muscle. In animal models, nicardipine produced relaxation of coronary vascular smooth muscle at drug levels which cause little or no negative inotropic effect.

References

1. ^ Huang RI, Patel P, Walinsky P, et al. (November 2006). "Efficacy of intracoronary nicardipine in the treatment of no-reflow during percutaneous coronary intervention". Catheter Cardiovasc Interv 68 (5): 671–6. doi:10.1002/ccd.20885. PMID 17034064. 

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Calcium channel blockers Dihydropyridines Nitrobenzenes Carboxylate esters Amines Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат John Lundberg East Wind Community Look at other dictionaries: Nicardipine — Général Nom IUPAC 4 (3 nitrophényl) 2,6 diméthyl 1,4 dihydropyridine 3,5 dicarboxylate de méthyle et de 2 [benzyl(méthyl)amino]éthyle …   Wikipédia en Français Nicardipine — HИКАРДИПИН ( Nicardipine )*. Cинонимы: Barazin, Cardene, Decarel, Loxen, Nicardal, Nicodel, Perdipine, Raxen и др. Производное 1,4 дигидропиридина. По структуре и действию близок к нифедипину. Применяют при стенокардии напряжения и покоя.… …   Словарь медицинских препаратов nicardipine — Calcium channel blocker used to treat hypertension …   Dictionary of molecular biology nicardipine — noun A calcium channel blocker used to treat high blood pressure and angina …   Wiktionary nicardipine — A calcium channel blocker of the dihydropyridine series; used as an antihypertensive and antianginal agent. * * * ni·car·di·pine .nī kär də .pēn n a calcium channel blocker administered orally in the form of its hydrochloride C26H29N3O6·HCl to… …   Medical dictionary nicardipine — n. a calcium channel blocker used to prevent angina and treat hypertension. It is administered by mouth. Possible side effects include nausea, chest pain, dizziness, headache, flushing, and palpitations. Trade names: Cardene …   The new mediacal dictionary nicardipine hydrochloride — ni·car·di·pine hy·dro·chlo·ride (ni kahrґdĭ pēn) a calcium channel blocking agent structurally related to nifedipine that acts as a vasodilator; administered orally in the treatment of angina pectoris and hypertension …   Medical dictionary Никардипин (Nicardipine) — антагонист кальция, применяемый для долговременного лечения стенокардии. Назначается внутрь. Возможные побочные эффекты: тошнота, боль в груди, головокружение, головная боль, приливы крови к лицу и тахикардия. Торговое название: карден (Cardene) …   Медицинские термины 55985-32-5 — Nicardipine Nicardipine Général No CAS …   Wikipédia en Français C26H29N3O6 — Nicardipine Nicardipine Général No CAS …   Wikipédia en Français 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”