- Flunarizine
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Flunarizine Systematic (IUPAC) name 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine Clinical data AHFS/Drugs.com Micromedex Detailed Consumer Information Pregnancy cat. ? Legal status ? Identifiers CAS number 52468-60-7 ATC code N07CA03 PubChem CID 941361 DrugBank DB04841 ChemSpider 819216 UNII R7PLA2DM0J KEGG D07971 ChEMBL CHEMBL30008 Synonyms 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine Chemical data Formula C26H26F2N2 Mol. mass 404.495 SMILES eMolecules & PubChem (what is this?) (verify)
Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia. Flunarizine was discovered at Janssen Pharmaceutica in 1967.
Brand Name
- Sibelium by Janssen Pharmaceutica.
References
- Van Nueten JM, Janssen PA., Comparative study of the effects of flunarizine and cinnarizine on smooth muscles and cardiac tissues, Arch Int Pharmacodyn Ther. 1973 Jul;204(1):37-55.
- Amery WK., Flunarizine, a calcium channel blocker: a new prophylactic drug in migraine, Headache. 1983 Mar;23(2):70-4.
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