Channel blocker

A channel blocker (CB) or ion channel blocker (ICB) is a type of drug which binds inside the pore of a specific type of ion channel and blocks the flow of ions through it, resulting in an alteration of the electrochemical gradient of the cell membrane of neurons and therefore a change in neurotransmission.

Types of Channel Blockers

There are several different major classes of channel blockers, including:

• Calcium (Ca²⁺) channel blockers
• ligand-gated ion channels (LGICs) via binding to their pore also exist:
  • 5-HT₃ receptor antagonists
  • AMPA receptor antagonists
  • GABA_A receptor antagonists
  • Glycine receptor antagonists
  • Kainate receptor antagonists
  • nACh receptor antagonists
  • NMDA receptor antagonists
  • P2X receptor antagonists
  • Zinc (Zn²⁺)-activated channel antagonists

  These types of receptor antagonists are referred to as noncompetitive or uncompetitive.

  See also

  • Ion channel

  References

  
  

  This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Ion channel blockers Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Channel architecture Channel catfish virus Look at other dictionaries: Calcium channel blocker — A calcium channel blocker (CCB) is a chemical that disrupts the movement of calcium (Ca2+) through calcium channels.[1] CCB drugs devised to target neurons are used as antiepileptics. However, the most widespread clinical usage of calcium channel …   Wikipedia Sodium channel blocker — Sodium channel blockers are agents used in the treatment of cardiac arrhythmia. They are classified as Type I in the Vaughan Williams classification.Antiarrhythmic The class I antiarrhythmic agents interfere with the (Na+) channel.Class I agents… …   Wikipedia calcium channel blocker — n any of a class of drugs (as verapamil) that prevent or slow the influx of calcium ions into smooth muscle cells esp. of the heart and that are used esp. to treat some forms of angina pectoris and some cardiac arrhythmias called also calcium… …   Medical dictionary calcium channel blocker — n. any of a class of drugs, including nifedipine, diltiazem, and verapamil, that relax vascular and other smooth muscle tissue by preventing calcium ions from entering their cells, used to treat headaches, high blood pressure, angina pectoris,… …   Universalium calcium channel blocker — n. any of a class of drugs, including nifedipine, diltiazem, and verapamil, that relax vascular and other smooth muscle tissue by preventing calcium ions from entering their cells, used to treat headaches, high blood pressure, angina pectoris,… …   English World dictionary Potassium channel blocker — Potassium channel blockers are agents which interfere with conduction through potassium channels.ArrhythmiaPotassium channel blockers used in the treatment of cardiac arrhythmia are classified as class III antiarrhythmic agents.MechanismClass III …   Wikipedia calcium-channel blocker — noun any of a class of drugs that block the flow of the electrolyte calcium (either in nerve cell conduction or smooth muscle contraction of the heart); has been used in the treatment of angina or arrhythmia or hypertension or migraine • Syn:… …   Useful english dictionary calcium channel blocker — noun or calcium blocker : any of a class of drugs (as verapamil) that prevent or slow the influx of calcium ions into smooth muscle cells especially of the heart and that are used especially to treat some forms of angina pectoris and some cardiac …   Useful english dictionary potassium channel blocker — potassium channel blocking agent …   Medical dictionary sodium channel blocker — sodium channel blocking agent …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”