Ganglionic blocker

Ganglionic blocker

A ganglionic blocker (or ganglioplegic) is a type of medication which inhibits postganglionic transmission,cite web |url=http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/four/000043626.htm |title=Dorlands Medical Dictionary:ganglioplegic |format= |work= |accessdate=] primarily by acting as a nicotinic antagonist. [MeshName|Ganglionic+blockers]

Because ganglonic blockers block the parasympathetic nervous system and sympathetic nervous system, the effect of these drugs depend upon the dominant tone in the organ system. cite web |url=http://www.med.howard.edu/pharmacology/handouts/autono4.htm |title=PHARMACOLOGY OF GANGLIONIC TRANSMISSION, 1998 |format= |work= |accessdate=2008-10-04]

Examples

Examples include hexamethonium, pentolinium, mecamylamine, trimetaphan and pempidine.

Others include: [MeshPharmaList|82005730]
* benzohexonium
* chlorisondamine
* pentamine

Uses

Ganglionic blockers are used less frequently now than they were in the past, because more selective agents are now available. However, they are still used in some emergency situations, such as aortic dissection.

References


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