Nifekalant

Nifekalant: Nifekalant

Systematic (IUPAC) name

6-[(2-{(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino}ethyl)amino]-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

Clinical data

AHFS/Drugs.com International Drug Names

Pregnancy cat. ?

Legal status ℞ Prescription only

Routes IV

Identifiers

CAS number 130636-43-0

ATC code None

PubChem CID 4486

UNII 5VZ7GZM43E^Y

Chemical data

Formula C₁₉H₂₇N₅O₅

Mol. mass 405.44 g/mol

SMILES eMolecules & PubChem

Y(what is this?) (verify)

Nifekalant (INN) is a class III antiarrhythmic agent approved in Japan for the treatment of arrhythmias and ventricular tachycardia.^[1] It has the brand name Shinbit.

References

^ Oyabe A, Sano H (February 2002). "[Pharmacological and clinical profile of nifekalant (shinbit injection), a class III antiarrhythmic drug"] (in Japanese) (^{[dead link]} – ^{Scholar search}). Nippon Yakurigaku Zasshi 119 (2): 103–9. doi:10.1254/fpj.119.103. PMID 11862758. http://joi.jlc.jst.go.jp/JST.JSTAGE/fpj/119.103?lang=en&from=PubMed.

v · d · eChannel blocker: potassium channel blockers

Antiarrhythmic III/delayed rectifier
benzofuran (Amiodarone) • quaternary ammonium (Bretylium) • naphthalene (Bunaftine) • phenethylamine (Dofetilide) • sulfonamide (Ibutilide) • pyrimidinone (Nifekalant) • ethanolamine (Sotalol) • cyclopropane (Tedisamil) • E-4031

Other/ungrouped/unknown
aminopyridines (3,4-Diaminopyridine, 4-Aminopyridine) • indole (Linopirdine, Paxilline) • quaternary ammonium (Tetraethylammonium) • peptide (Maurotoxin, Charybdotoxin)

v · d · eAntiarrhythmic agents (C01B)

Channel blockers

class I
(Na⁺ channel blockers)

class Ia (Phase 0→ and Phase 3→)

Procainamide # • Quinidine # • Ajmaline • Disopyramide • Prajmaline • Lorajmine • Sparteine

class Ib (Phase 3←)

IV (Lidocaine #) • enteral (Mexiletine, Tocainide, Aprindine)

class Ic (Phase 0→)

Encainide • Flecainide • Lorcainide • Moricizine‡ • Propafenone

class III
(Phase 3→, K⁺ channel blockers)

Amiodarone • Dronedarone • Bretylium • Bunaftine • Dofetilide • Ibutilide • Nifekalant • Sotalol • Tedisamil • Vernakalant • E-4031

class IV
(Phase 4→, Ca²⁺ channel blockers)

Verapamil # • Diltiazem

Receptor agonists
and antagonists

class II
(Phase 4→, β blockers)

Propranolol • Nadolol • Pindolol • cardioselective (Atenolol, Metoprolol, Acebutolol, Esmolol)

A1 agonist

Adenosine

M2

muscarinic antagonist: Atropine • Quinidine • Disopyramide
muscarinic agonist: Digoxin

α receptors

Quinidine • Verapamil • Amiodarone • Bretylium

Ion transporters

Na⁺ / K⁺-ATPase

Digoxin

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: HRT

anat/phys/devp

noco/cong/tumr, sysi/epon, injr

proc, drug (C1A/1B/1C/1D), blte

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Nifekalant

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Systematic (IUPAC) name
6-[(2-{(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino}ethyl)amino]-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	IV
Identifiers
CAS number	130636-43-0
ATC code	None
PubChem	CID 4486
UNII	5VZ7GZM43E^Y
Chemical data
Formula	C₁₉H₂₇N₅O₅
Mol. mass	405.44 g/mol
SMILES	eMolecules & PubChem
Y(what is this?) (verify)

Academic Dictionaries and Encyclopedias

Wikipedia

Nifekalant

References

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