Moricizine

Moricizine

Systematic (IUPAC) name
ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate
Clinical data
Trade names	Ethmozine
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a601214
Pregnancy cat.	B (U.S.)
Legal status	?
Pharmacokinetic data
Bioavailability	38%
Protein binding	95%
Half-life	3-4 hours (healthy volunteers), 6-13 hours (cardiac disease)
Identifiers
CAS number	31883-05-3 Y
ATC code	None
PubChem	CID 34633
DrugBank	APRD01124
ChemSpider	31872 Y
UNII	2GT1D0TMX1 Y
KEGG	D05077 Y
ChEBI	CHEBI:6997 N
ChEMBL	CHEMBL1075 Y
Chemical data
Formula	C22H25N3O4S
Mol. mass	427.518 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27) Y Key:FUBVWMNBEHXPSU-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Moricizine (Ethmozine®) is a phenothiazine derivative with Vaughan Williams class Ic antiarrhythmic properties. It undergoes extensive first-pass metabolism, has a bioavailability of 34-38 percent, and is 95 percent bound to plasma proteins. Moricizine is extensively metabolized and may have pharmacologically active metabolites. A recent clinical study has shown that moricizine is slightly less effective than encainide or flecainide in suppressing ventricular premature depolarizations^{[citation needed]}. Compared with disopyramide and quinidine, moricizine was equally or more effective in suppressing ventricular premature depolarizations, couplets, and nonsustained ventricular tachycardia^{[citation needed]}. Further studies are needed comparing moricizine with other class 1 agents in the treatment of life-threatening arrhythmias; available data suggest that moricizine is comparable with these agents in the treatment of ventricular tachycardias and fibrillation. Moricizine appears to have a low incidence of serious adverse effects compared with other antiarrhythmics. This combination of apparently similar efficacy with a decreased incidence of adverse effects makes moricizine a worthwhile addition to currently available antiarrhythmic agents.

External links

• Moricizine
• MedlinePlus DrugInfo medmaster-a601080

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Antiarrhythmic agents Phenothiazines Morpholines Carbamates Sodium channel blockers Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Adamantisaurus PlayNetwork Look at other dictionaries: moricizine — noun A phenothiazine derivative with antiarrhythmic properties …   Wiktionary moricizine — mo·ric·i·zine mə ris ə .zēn n an antiarrhythmic drug used in the form of its hydrochloride C22H25N3O4S·HCl esp. in the treatment of life threatening ventricular arrhythmias …   Medical dictionary moricizine hydrochloride — mor·i·ci·zine hy·dro·chlo·ride (mor ĭґsĭ zēn) [USP] a phenothiazine derivative used as an antiarrhythmic in the treatment of ventricular arrhythmias; administered orally …   Medical dictionary Antiarrhythmic agent — The cardiac action potential Antiarrhythmic agents are a group of pharmaceuticals that are used to suppress abnormal rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular …   Wikipedia Categories de medicaments — Catégories de médicaments (Voir aussi : Classification anatomique, thérapeutique et chimique) Sommaire 1 Classification générale 1.1 Analgésiques et Anti inflammatoires 1.2 Antibiotiques et Antibactériens …   Wikipédia en Français Catégories de médicaments — (Voir aussi : Classification anatomique, thérapeutique et chimique) Sommaire 1 Classification générale 1.1 Analgésiques et Anti inflammatoires 1.2 Antibiotiques et Antibactériens …   Wikipédia en Français Phenytoin — Systematic (IUPAC) name 5,5 diphenylimidazolidine …   Wikipedia Adenosine — Systematic (IUPAC) name (2R,3R,4S,5R …   Wikipedia Cardioversion — Intervention ICD 9 CM 99.6 MeSH …   Wikipedia Magnesium sulfate — Anhydrous magnesium sulfate Epsomite (heptahydrate) …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”