Mexiletine

Mexiletine

Systematic (IUPAC) name
(RS)-1-(2,6-dimethylphenoxy)propan-2-amine OR 2-(2-aminopropoxy)-1,3-dimethylbenzene
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a607064
Pregnancy cat.	B1(AU) C(US)
Legal status	POM (UK)
Routes	Oral, IV
Pharmacokinetic data
Bioavailability	90%
Protein binding	50-60%
Metabolism	Hepatic (CYP2D6 and 1A2- mediated)
Half-life	10-12 hours
Excretion	Renal (10%)
Identifiers
CAS number	31828-71-4 Y
ATC code	C01BB02
PubChem	CID 4178
IUPHAR ligand	2629
DrugBank	APRD00242
ChemSpider	4034 Y
UNII	1U511HHV4Z Y
KEGG	D08215 Y
ChEBI	CHEBI:6916 N
ChEMBL	CHEMBL558 Y
Chemical data
Formula	C11H17NO
Mol. mass	179.259 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3 Y Key:VLPIATFUUWWMKC-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Mexiletine (INN, sold under the trade name Mexitil) belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart, or seriously irregular heartbeats. It slows conduction in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.

Class IB antiarrhythmics decrease action potential duration by shortening the repolarization phase. This is achieved by blocking sodium channels.^[1]

Mexiletine may also be of use in patients experiencing refractory pain^[2] and is also effective for treating muscle stiffness resulting from myotonia congenita (Thomsen disease) or myotonic dystrophy (Steinert's disease).

References

1. ^ Mexiletine, RxList.com
2. ^ Sweetman S (ed.) (2002). Martindale: The complete drug reference (33rd ed. ed.). London: Pharmaceutical Press. ISBN 0-85369-499-0. 

Further reading

• Peck T; Hill S, Williams M (eds.) (2004). Pharmacology for Anaesthesia and Intensive Care (2nd ed. ed.). Cambridge University Press. ISBN 0-521-68794-2. 

External links

• MedlinePlus Drug Information: Mexiletine

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Sodium channel blockers Phenol ethers Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Lancia Lybra The Peanut Butter Conspiracy Look at other dictionaries: mexiletine — A cardiac antiarrhythmic drug used to treat ventricular arrhythmias; resembles lidocaine in its actions but is orally effective. * * * n. an anti arrhythmic drug used in the treatment or prevention of severe heart irregularity arising in the… …   Medical dictionary mexiletine — n. an anti arrhythmic drug used in the treatment or prevention of severe heart irregularity arising in the lower chambers (ventricles). It is administered by mouth or injection. Possible side effects include nausea and vomiting, dizziness, and… …   The new mediacal dictionary mexiletine — noun antiarrhythmic drug (trade name Mexitil) used to treat ventricular arrhythmias • Syn: ↑Mexitil • Usage Domain: ↑trade name (for: ↑Mexitil) • Hypernyms: ↑antiarrhythmic, ↑ …   Useful english dictionary Mexiletine hydrochloride — МЕКСИЛЕТИН ( Мехiletine hydroсhlоridе )*. 1 Метил 2 (2,6 ксилилокси) этиламина гидрохлорид. Синонимы: Мекситил, Мехilen, Мехitec, Меxitil, Мехitilen, Мохitil, Таmetil. По химической структуре близок к лидокаину и, подобно последнему, оказывает… …   Словарь медицинских препаратов mexiletine hydrochloride — An orally active antiarrhythmic agent used to suppress symptomatic ventricular arrhythmias; resembles lidocaine in its actions but is orally effective. * * * mex·il·e·tine hy·dro·chlo·ride (mekґsĭ lə tēn) an oral antiarrhythmic… …   Medical dictionary Мексилетин (Mexiletine) — противоаритмическое лекарственное вещество; применяется для предотвращения или лечения сильной аритмии, возникающей в желудочках сердца. Назначается внутрь. Возможные побочные эффекты: тошнота, рвота, головокружение и двоение зрения. Торговое… …   Медицинские термины МЕКСИЛЕТИН — (mexiletine) противоаритмическое лекарственное вещество; применяется для предотвращения или лечения сильной аритмии, возникающей в желудочках сердца. Назначается внутрь. Возможные побочные эффекты: тошнота, рвота, головокружение и двоение зрения …   Толковый словарь по медицине Long QT syndrome — Infobox Disease Name = Long QT syndrome(Romano Ward syndrome) Caption = Schematic representation of normal ECG trace (sinus rhythm), with waves, segments, and intervals labeled. DiseasesDB = 11104 ICD10 = ICD10|I|45|8|i|30 ICD9 = ICD9|426.82 ICDO …   Wikipedia Antiarrhythmic agent — The cardiac action potential Antiarrhythmic agents are a group of pharmaceuticals that are used to suppress abnormal rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular …   Wikipedia Mexiletin — Strukturformel (R) Isomer (oben) und (S) Isomer (unten) …   Deutsch Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”