Biogenic amine

Biogenic amine

A biogenic amine is a biogenic substance with an amine group.


Some prominent examples of biogenic amines include:

* Histamine - a substance derived from the amino acid histidine that acts as a neurotransmitter mediating arousal and attention, as well as a pro-inflammatory signal released from mast cells in response to allergic reactions or tissue damage. Histamine is also an important stimulant of HCl secretion by the stomach through histamine H2 receptors.
* Tyramine - a substance that is found in many common foods, and is associated with increased blood pressure and headaches.
* Serotonin - a central nervous system neurotransmitter involved in regulating mood, sleep, appetite, and sexuality.
* The three catecholamine neurotransmitters:
** Norepinephrine (noradrenaline) - a neurotransmitter involved in sleep and wakefulness, attention, and feeding behavior, as well as a stress hormone released by the adrenal glands that regulates the sympathetic nervous system.
** Epinephrine (adrenaline) - an adrenal stress hormone, as well as a neurotransmitter present at lower levels in the brain.
** Dopamine - a neurotransmitter involved in motivation, reward, addiction, behavioral reinforcement, and coordination of bodily movement.
*Tryptamine - a monoamine alkaloid found in trace amounts in the brains of mammals, and believed to play a role as a neuromodulator or neurotransmitter.

Physiological importance

There is a distinction between endogenous and exogenous biogenic amines. Endogenous amines are produced in many different tissues (for example: adrenaline in adrenal medulla or histamine in mast cells and liver). The amines are transmitted locally or via the blood system. The exogenous amines are directly absorbed from food in the intestine. Alcohol can increase the absorption rate. The monoamineoxidase (MAO) breaks down biogenic amines and prevents excessive resorption. MAOIs are also used as medications for the treatment of depression to prevent MAO from breaking down amines important for positive mood.

External links

* [ The Biogenic Amines] - "Neuroscience" 2nd edition, Dale Purves et al

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Biogenic amine receptor — are a variety of neurotransmitter receptors that are sensitive to biogenic amine neurotransmitters. These are inthe family of Rhodopsin like receptors, primarily within the G protein coupled receptor (GPCR) family of transmembrane… …   Wikipedia

  • biogenic amine — a type of amine synthesized by both plants and animals and frequently involved in signaling; prominent examples are neurotransmitters such as acetylcholine, catecholamines, and serotonin. Others are hormones or components of vitamins,… …   Medical dictionary

  • biogenic amine hypothesis — the hypothesis that depression is associated with deficiency of biogenic amines (catecholamines and serotonin), especially norepinephrine, at functionally important receptor sites in the brain and that elation is associated with excess of such… …   Medical dictionary

  • Amine — For other uses, see Amine (disambiguation). Primary amine Secondary amine Tertiary amine …   Wikipedia

  • biogenic — Produced by a living organism. * * * bio·gen·ic jen ik adj produced by living organisms <biogenic amine metabolism in depressed patients (D. L. Murphy)> * * * bi·o·gen·ic (bi″o jenґik) having origins in biological processes, as a… …   Medical dictionary

  • Amine — A chemical compound containing nitrogen. Amines are derived from ammonia. (The name "amine" was derived from the word "ammonia.") * * * A substance formally derived from ammonia by the replacement of one or more of the… …   Medical dictionary

  • biogenic amines — a type of amine formed from decarboxylation of amino acids in spoiled fish by the action of bacteria at temperatures above 10°C. Includes histamine (from histidine), cadaverine (from lysine), putrescine (from arginine), agmatine, spermine,… …   Dictionary of ichthyology

  • Trace amine-associated receptor — Trace amine associated receptors, abbreviated TAAR and previously abbreviated TAR and TA, are a class of G protein coupled receptors identified in 2001.cite journal |author=Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL,… …   Wikipedia

  • Trace amine — Trace amines are endogenous compounds structurally related to classical biogenic amines, such as catecholamines, serotonin and histamine. Trace amines include p tyramine, β phenylethylamine, tryptamine, octopamine, and 3 iodothyronamine, and are… …   Wikipedia

  • biogenicamine — biogenic amine n. Any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, that act primarily as neurotransmitters and are capable of affecting mental functioning and of regulating blood …   Universalium

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”