Mibefradil

Mibefradil
Mibefradil
Systematic (IUPAC) name
(1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl) (methyl)amino)ethyl)-6-fluoro-1-isopropyl- 1,2,3,4-tetrahydronaphthalen-2-yl 2-methoxyacetate
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a607007
Pregnancy cat.  ?
Legal status Withdrawn from market
Routes Oral
Identifiers
CAS number 116644-53-2 YesY
ATC code C08CX01
PubChem CID 60662
DrugBank DB01388
UNII 27B90X776A N
KEGG D08217 YesY
ChEMBL CHEMBL45816 N
Chemical data
Formula C29H38FN3O3 
Mol. mass 495.63 g/mol
 N(what is this?)  (verify)

Mibefradil (Posicor) is a drug for the treatment of hypertension and chronic angina pectoris. It belongs to a group known as calcium channel blockers.

It is nonselective.[1]

On June 8, 1998, Roche announced the voluntary withdrawal of the drug from the market,[2] due to the potential for drug interactions, some of them serious, which may occur when it is taken together with some other medications.

References

  1. ^ Bezprozvanny I, Tsien RW (September 1995). "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Mol. Pharmacol. 48 (3): 540–9. PMID 7565636. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7565636. 
  2. ^ Letter from Roche Laboratories: http://www.fda.gov/medwatch/SAFETY/1998/poscor.htm
v · d · eChannel blocker: calcium channel blockers (C08)
Selective
Dihydropyridines ("-dipine")
Amlodipine# • Aranidipine • Azelnidipine • Barnidipine • Benidipine • Cilnidipine • Clevidipine • Darodipine • Efonidipine • Felodipine • Isradipine • Lacidipine • Manidipine • Lercanidipine • Mepirodipine • Nicardipine • Nifedipine# • Niludipin • Nilvadipine • Nimodipine • Nisoldipine • Nitrendipine • Oxodipine • Pranidipine • Ryodipine
Phenylalkylamines ("-pamil")
Anipamil  • Devapamil • Emopamil • Falipamil  • Gallopamil • Norverapamil  • Verapamil
1-4 Benzothiazepines ("-tiazem")
Non-selective
Bepridil • Fendiline • Lidoflazine • Perhexiline
Other/ungrouped
Amrinone  • Anandamide  • Azimilide  • Bencyclane  • Berbamine  • Bevantolol • Canadine • Carboxyamidotriazole  • Caroverine  • Cinnarizine  • Conotoxins  • Dauricine  • Dimeditiapramine • Dotarizine • Enpiperate  • Eperisone • Fantofarone  • Fasudil  • Fenamic acid  • Flunarizine  • Fostedil • Gabapentin  • Lamotrigine  • Magnesium sulfate  • Manoalide • Mibefradil‡  • Monatepil  • Naftopidil  • Niguldipine  • Ochratoxin A • Octylonium  • Osthol  • Pinaverium  • Piperidine  • Pregabalin  • Prenylamine  • Risedronic acid • Sesamodil  • Stepholidine  • Terodiline  • Tetrahydropalmatine  • Tetrandrine  • Tolfenamic acid • Tranilast  • TROX-1  • Ziconotide

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)


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