Nisoldipine

Nisoldipine

Systematic (IUPAC) name
isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a696009
Pregnancy cat.	C(US)
Legal status	℞-only (US)
Routes	Oral
Pharmacokinetic data
Protein binding	99%
Half-life	7-12 hours
Identifiers
CAS number	63675-72-9 Y
ATC code	C08CA07
PubChem	CID 4499
DrugBank	APRD00635
ChemSpider	4343 N
UNII	4I8HAB65SZ N
KEGG	D00618 Y
ChEMBL	CHEMBL1726 N
Chemical data
Formula	C20H24N2O6
Mol. mass	388.414 g/mol
N(what is this?)  (verify)

Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. It sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels. ^[1]

External links

• DDB 30009
• Mielcarek J, Grobelny P, Szamburska O (2005). "The effect of beta-carotene on the photostability of nisoldipine.". Methods Find Exp Clin Pharmacol 27 (3): 167–71. doi:10.1358/mf.2005.27.3.890873. PMID 15834448. 
• Missan S, Zhabyeyev P, Dyachok O, Jones SE, McDonald TF (November 2003). "Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine". Br. J. Pharmacol. 140 (5): 863–70. doi:10.1038/sj.bjp.0705518. PMC 1574108. PMID 14530219. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1574108. 
• Hamilton S, Houle L, Thadani U (1999). "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.". Heart Dis 1 (5): 279–88. PMID 11720635. 

References

1. ^ http://www.sciencedirect.com/science/article/pii/S0002914999804469; Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Calcium channel blockers Dihydropyridines Carboxylate esters Nitrobenzenes Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Leo Tornikios Kontoleon Bayview Woods-Steeles Look at other dictionaries: Nisoldipine — Général Nom IUPAC isobutyl methyl 2,6 dimethyl 4 (2 nitrophenyl) 1,4 dihydropyridine 3,5 dicarboxylate No …   Wikipédia en Français nisoldipine — noun A calcium channel blocker of the dihydropyridine class …   Wiktionary nisoldipine — A calcium channel blocker of the dihydropyridine series; used as an antihypertensive and antianginal agent. * * * ni·sol·di·pine (ni solґdĭ pēn) a calcium channel blocking agent used in the treatment of hypertension; administered orally …   Medical dictionary NICOLE — Nisoldipine in Coronary Artery Disease in Leuven …   Medical dictionary NICOLE — • Nisoldipine in Coronary Artery Disease in Leuven …   Dictionary of medical acronyms & abbreviations Dihydropyridine — Systematic name 1,4 Dihydropyridine[1] …   Wikipedia Calcium channel blocker — A calcium channel blocker (CCB) is a chemical that disrupts the movement of calcium (Ca2+) through calcium channels.[1] CCB drugs devised to target neurons are used as antiepileptics. However, the most widespread clinical usage of calcium channel …   Wikipedia 3337-17-5 — Dihydropyridine Dihydropyridine Général Nom IUPAC 1,4 dyhydroazine Synonymes …   Wikipédia en Français Antagoniste Du Calcium — Bloqueurs de canaux calciques Les antagonistes du calcium freinent l entrée du calcium dans les cellules, surtout au niveau du système cardio vasculaire, mais les différentes classes exercent toutefois des effets sensiblement différents.… …   Wikipédia en Français Antagoniste du calcium — Bloqueurs de canaux calciques Les antagonistes du calcium freinent l entrée du calcium dans les cellules, surtout au niveau du système cardio vasculaire, mais les différentes classes exercent toutefois des effets sensiblement différents.… …   Wikipédia en Français 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”