Oxaflozane

Oxaflozane
Oxaflozane
Systematic (IUPAC) name
4-propan-2-yl-2-[3-(trifluoromethyl)phenyl]morpholine
Clinical data
Pregnancy cat.  ?
Legal status ℞ Prescription only
Routes Oral
Identifiers
CAS number 26629-86-7
ATC code N06AX10
PubChem CID 432824
ChemSpider 382782
UNII V4WLW77V5Q YesY
KEGG D07340
Chemical data
Formula C14H18F3NO 
Mol. mass 273.29 g/mol
SMILES eMolecules & PubChem

Oxaflozane (Conflictan) is an antidepressant and anxiolytic drug that was introduced in France in 1982 by Solvay for the treatment of depression, but has since been abandoned.[1][2] It is a prodrug to non-selective serotonin receptor agonist for the 5-HT1A (pKi = 7.1), 5-HT2A (pKi = 6.0), and 5-HT2C (pKi = 7.5) subtypes.[3] Oxaflozane may also have anticholinergic effects in high doses.[4]

References

  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 766. ISBN 3-88763-075-0. http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA766&dq=oxaflozane%20conflictan&as_brr=3&pg=PA766#v=onepage&q=&f=false. 
  2. ^ Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. p. 1122. ISBN 0-8155-1144-2. http://books.google.com/books?id=XCsJgUnclbcC&lpg=PA1122&dq=oxaflozane%20conflictan&as_brr=3&pg=PA1122#v=onepage&q=&f=false. 
  3. ^ Leysen DC (February 1999). "Selective 5-HT2C agonists as potential antidepressants". IDrugs : the Investigational Drugs Journal 2 (2): 109–20. PMID 16160946. 
  4. ^ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). "Oxaflozane overdose in a child". Journal of Toxicology. Clinical Toxicology 30 (1): 123–6. PMID 1542141. 

Further reading

  • Rascol A, Maurel H, David J, Layani M (1974). "[Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]" (in French). Thérapie 29 (1): 95–9. PMID 4603757. 
  • Hache J, Duchene-Marullaz P, Streichenberger G (1974). "[Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]" (in French). Thérapie 29 (1): 81–93. PMID 4849381. 
  • Constantin M, Pognat JF (1979). "Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites". Arzneimittel-Forschung 29 (1): 109–14. PMID 582104. 
  • Bertolino A, palermo M, Porro V (1985). "Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes.". Acta Ther (11): 209–218. 
  • Aguglia E (1986). "On the therapetic value of axaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations.". Acta Ther (12): 259–267. 

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M: PSO/PSI

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dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

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