Rizatriptan

Rizatriptan
Rizatriptan
Systematic (IUPAC) name
N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
Clinical data
Trade names Maxalt
AHFS/Drugs.com monograph
MedlinePlus a601109
Pregnancy cat. C
Legal status ℞ Prescription only
Routes Oral
Pharmacokinetic data
Bioavailability 45%
Protein binding 14%
Metabolism by monoamine oxidase
Half-life 2–3 hours
Excretion 82% urine; 12% faeces
Identifiers
CAS number 145202-66-0 YesY
ATC code N02CC04
PubChem CID 5078
IUPHAR ligand 51
DrugBank APRD00008
ChemSpider 4900 YesY
UNII WR978S7QHH YesY
KEGG D00675 N
ChEBI CHEBI:48273 N
ChEMBL CHEMBL905 YesY
Chemical data
Formula C15H19N5 
Mol. mass 269.345 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Rizatriptan (Maxalt) is a 5-HT1 agonist triptan drug developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).

Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.

Rizatriptan is available only by prescription in Australia, the United States, Canada and New Zealand. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom, Italy (as Rizaliv), Israel (as Rizalt), The Netherlands (as Maxalt), Croatia (as Maxalt) and Spain (as Maxalt)

Contents

Use

Rizatriptan is used to treat acute migraine attacks. It does not prevent future migraine attacks.

Indications

Contraindications

Adverse effects

Severe:

Atypical sensations:

Cardiovascular:

Ear, nose, and throat:

Gastrointestinal:

Muscular:


Neurological:

Respiratory:

Skin:

Miscellaneous:

External links

v · d · eAntimigraine preparations (N02C)
Analgesic/abortive
Serotonin modulators
Ergot alkaloids
Other
Other
Prevention of migraines
valproate • carbamazepine • oxcarbazepine
Ungrouped
Pizotifen • Iprazochrome • Dimetotiazine • Oxetorone • Lomerizine • Telcagepant

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)
v · d · eTryptamines

1-(2-Dimethylaminoethyl)dihydropyrano(3,2-e)indole • 2-Methyl-5-HT • 4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-Acetoxy-DMT • 4-HO-αMT • 4-HO-DIPT • 4-HO-MET • 4-MeO-DMT • 4-Methyl-αET • 4-Methyl-αMT • 5-Benzyloxytryptamine • 5-Bromo-DMT • 5-Carboxamidotryptamine • 5-Ethoxy-αMT • 5-Fluoro-αMT • 5-HO-αMT • 5-HTP • 5-Ethoxy-DMT • 5-Ethyl-DMT • 5-Fluoro-DMT • 5-Methyl-DMT • 5-Methoxytryptamine • 5-MeO-7,N,N-TMT • 5-Methyl-αET • 5-MeO-αET  • 5-MeO-αMT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-MALT • 5-MeO-MIPT • 5,7-Dihydroxytryptamine • 5-(Nonyloxy)tryptamine • 6-Fluoro-αMT • 7-Methyl-αET • 7-Methyl-DMT • αET • αMT • Aeruginascin • AL-37350A • BW-723C86 • Baeocystin • Bufotenidine • Bufotenin • DALT • Desformylflustrabromine • DET • DiPT • DMT • DPT • Ethocybin • EiPT • EMDT • EPT • Ethocin • FGIN-127 • FGIN-143 • Ibogaine • Indorenate • Iprocin • MET • MiPT • Miprocin • Melatonin • MS-245 • NAS • NMT • Norbaeocystin • Normelatonin • Oxypertine • PiPT • Psilocin • Psilocybin • Rizatriptan • Serotonin • Sumatriptan • Tryptamine • Tryptophan • Yohimbine • Yuremamine • Zolmitriptan
v · d · eMerck & Co., Inc.
Corporate directors:
Richard Clark · Johnnetta Cole · William Harrison · William Kelley · Rochelle Lazarus · Thomas Shenk · Anne Tatlock · Samuel Thier · Wendell Weeks · Peter Wendell
Products:
Publications:
The Merck Manuals (Index · Manual · Veterinary · USD (increase2% FY 2004) · Employees: 63,000 · Stock Symbol: NYSE: MRK · Website: merck.com


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