Caption =
DiseasesDB = 28827
ICD10 = ICD10|T|78|4|t|66
ICD9 = ICD9|995.3
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID = D006967

Hypersensitivity (also called hypersensitivity reaction) refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system. Hypersensitivity reactions require a pre-sensitized (immune) state of the host. The four-group classification was expounded by P. H. G. Gell and Robin Coombs in 1963. [Gell PGH, Coombs RRA, eds. Clinical Aspects of Immunology. 1st ed. Oxford, England: Blackwell; 1963.]

Coombs and Gell classification

Type 5

This is an additional type that is sometimes (often in Britain) used as a distinction from Type 2.cite journal |author=Rajan TV |title=The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation |journal=Trends Immunol. |volume=24 |issue=7 |pages=376–9 |year=2003 |month=July |pmid=12860528 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S147149060300142X]

Instead of binding to cell surface components, the antibodies recognize and bind to the cell surface receptors, which either prevents the intended ligand binding with the receptor or mimics the effects of the ligand, thus impairing cell signalling.

Some clinical examples:
*Graves disease
*Myasthenia gravis

The use of "Type 5" is rare. These conditions are more frequently classified as Type 2, though sometimes they are specifically segregated into its own subcategory of Type 2.


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Look at other dictionaries:

  • hypersensitivity — hypersensitivity. См. гиперчувствительность. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hypersensitivity — In immunology, a state of excessive and potentially damaging immune responsiveness as a result of previous exposure to antigen. If the hypersensitivity is of the immediate type (antibody mediated), then the response occurs in minutes; in delayed… …   Dictionary of molecular biology

  • hypersensitivity — Abnormal sensitivity, a condition in which there is an exaggerated response by the body to the stimulus of a foreign agent. See allergy. contact h. 1. SYN: contact dermatitis. 2. SYN: delayed reaction. delayed h. 1 …   Medical dictionary

  • hypersensitivity — See hypersensitiveness. * * *       acquired bodily state in which the reaction to a stimulus (e.g., a substance causing allergy or a physical agent such as light) is unusually prompt or excessive. The term hypersensitivity is often used as a… …   Universalium

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  • hypersensitivity — noun 1. pathological sensitivity • Derivationally related forms: ↑hypersensitive • Hypernyms: ↑sensitivity, ↑predisposition • Hyponyms: ↑cryesthesia, ↑cryaesthesia, ↑ …   Useful english dictionary

  • hypersensitivity — noun see hypersensitive …   New Collegiate Dictionary

  • hypersensitivity — (hi per sen si tiv i te) A condition of increased immune sensitivity in which the body reacts to an antigen with an exaggerated immune response that usually harms the individual. Also termed an allergy …   Dictionary of microbiology

  • hypersensitivity — noun any heightened immune response to an antigen; an allergy See Also: hypersensitive …   Wiktionary

  • hypersensitivity — Synonyms and related words: allergy, anaphylaxis, considerateness, delicacy, empathy, exquisiteness, fineness, hairsplitting, hypercriticism, hyperesthesia, hyperpathia, hypersensitiveness, identification, irritability, morbid sensibility,… …   Moby Thesaurus

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