Name = PAGENAME
DiseasesDB = 28827
ICD10 = ICD10|T|78|4|t|66
ICD9 = ICD9|995.3
MeshID = D006967
Hypersensitivity (also called hypersensitivity reaction) refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system. Hypersensitivity reactions require a pre-sensitized (immune) state of the host. The four-group classification was expounded by P. H. G. Gell and
Robin Coombsin 1963. [Gell PGH, Coombs RRA, eds. Clinical Aspects of Immunology. 1st ed. Oxford, England: Blackwell; 1963.]
Coombs and Gell classification
This is an additional type that is sometimes (often in Britain) used as a distinction from Type 2.cite journal |author=Rajan TV |title=The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation |journal=Trends Immunol. |volume=24 |issue=7 |pages=376–9 |year=2003 |month=July |pmid=12860528 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S147149060300142X]
Instead of binding to cell surface components, the antibodies recognize and bind to the cell surface receptors, which either prevents the intended
ligandbinding with the receptor or mimics the effects of the ligand, thus impairing cell signalling.
Some clinical examples:
The use of "Type 5" is rare. These conditions are more frequently classified as Type 2, though sometimes they are specifically segregated into its own subcategory of Type 2.
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