- Hypersensitivity
__NOTOC__Infobox_Disease
Name = PAGENAME
Caption =
DiseasesDB = 28827
ICD10 = ICD10|T|78|4|t|66
ICD9 = ICD9|995.3
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID = D006967Hypersensitivity (also called hypersensitivity reaction) refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system. Hypersensitivity reactions require a pre-sensitized (immune) state of the host. The four-group classification was expounded by P. H. G. Gell and
Robin Coombs in 1963. [Gell PGH, Coombs RRA, eds. Clinical Aspects of Immunology. 1st ed. Oxford, England: Blackwell; 1963.]Coombs and Gell classification
Type 5
This is an additional type that is sometimes (often in Britain) used as a distinction from Type 2.cite journal |author=Rajan TV |title=The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation |journal=Trends Immunol. |volume=24 |issue=7 |pages=376–9 |year=2003 |month=July |pmid=12860528 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S147149060300142X]
Instead of binding to cell surface components, the antibodies recognize and bind to the cell surface receptors, which either prevents the intended
ligand binding with the receptor or mimics the effects of the ligand, thus impairing cell signalling.Some clinical examples:
*Graves disease
*Myasthenia gravis The use of "Type 5" is rare. These conditions are more frequently classified as Type 2, though sometimes they are specifically segregated into its own subcategory of Type 2.
References
External links
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