Systematic (IUPAC) name
Clinical data
Pregnancy cat.  ?
Legal status Analogue of LSD and therefore controlled in the United States via the Federal Analog Act
Routes Oral
Pharmacokinetic data
Metabolism hepatic
Excretion renal
CAS number 3270-02-8
ATC code  ?
PubChem CID 201111
ChemSpider 174121 YesY
Synonyms 1-Acetyl-N,N-diethyllysergamide, ALD, N-acetyl-LSD, Acetyl lysergic acid diethylamide, d-acetyl lysergic acid diethylamide, d-acetyldiethyllysergamide
Chemical data
Formula C22H27N3O2 
Mol. mass 365.469 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

ALD-52, also known as N-acetyl-LSD, is a chemical analogue of lysergic acid diethylamide (LSD). It was originally discovered by Albert Hofmann but was not widely studied until the rise in popularity of psychedelics in the 1960s.



In TiHKAL, Shulgin touches briefly on ALD-52 in entry 26, LSD. His writings are vague, second hand accounts, saying doses in the 50-175 µg range have resulted in various conclusions. One found that there was less visual distortion than with LSD and it seems to produce less anxiety and was somewhat less potent than LSD. Another report claimed it was more effective in increasing blood pressure. Yet another could not tell them apart.

It has the same characteristics as LSD, but supposedly "without the anxiety, tenseness, and other problems inherent to it".


In The Hallucinogens by Hofmann and Osmond (1967), ALD-52 (D,L-acetyllysergic acid diethylamide) is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD.


It is possible ALD-52 was the active chemical in the "Orange Sunshine" LSD that was widely available in California through 1968 and 1969. The Sonoma County underground chemistry lab of Tim Scully and Nicholas Sand was the source for "Orange Sunshine." It was shut down by the police, and Scully was arrested and prosecuted. This resulted in the first drug analogue trial, where Scully claimed that he and his partners did nothing illegal, because they were producing ALD-52 which was not an illicit drug. However, as the prosecution claimed, there were problems with such a rationale: first, ALD-52 readily undergoes hydrolysis to LSD, and second, the synthesis of ALD-52 required LSD (this was based on the methods available in the scientific literature at the time). Scully was convicted and served time in prison.

See also


External links

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Look at other dictionaries:

  • ALD-52 — Химическое соединение …   Википедия

  • ALD — may refer to: *Ald (unit), An old Mongol measurement unit. *Activities of Limited Duration, or Appointments of Limited Duration, a contract modality within the United Nations *Alcoholic liver disease *Aldehyde dehydrogenase, and type of enzyme… …   Wikipedia

  • Ald — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom. {{{image}}}   Sigles d une seule lettre   Sigles de deux lettres > Sigles de trois lettres …   Wikipédia en Français

  • ald- — ⇒ALD(O) , (ALD , ALDO ), élément préf. ,,Préfixe indiquant la présence du groupement monovalent CHO. (DUVAL 1959). Tiré de aldéhyde et fonctionnant en oppos. avec l élément préf. céto ; est utilisé notamment pour la formation des termes de chimie …   Encyclopédie Universelle

  • ALD — Saltar a navegación, búsqueda Adrenoleucodistrofia Obtenido de ALD …   Wikipedia Español

  • ALD — Abreviatura de adrenoleucodistrofia. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • Ald — or Aldm abbrev. Alderman * * * …   Universalium

  • Ald- — vor Konsonanten Aldo [↑ Aldehyd] auf eine Beziehung zu Aldehyden verweisende Vorsilbe in Namen chemischer Verbindungsklassen, z. B. Aldarsäuren, Aldazine, Aldimine, Aldol …   Universal-Lexikon

  • Ald — (alderman) government official, member of a legislative body …   English contemporary dictionary

  • Ald — or Aldm abbrev. Alderman …   English World dictionary

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