8a-Phenyldecahydroquinoline

Drugbox
IUPAC_name = 8a-phenyl-2,3,4,4a,5,6,7,8-octahydro-1H-quinoline

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CAS_number= 131556-11-1
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PubChem= 131397
DrugBank=
C=15 | H=21 | N=1
molecular_weight = 215.3339 g/mol
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8a-Phenyldecahydroquinoline is a high affinity NMDA antagonist. It is a structural analog of Phencyclidine with slightly lower binding affinity than the parent compound. (-)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801. [cite journal|author=Chen C, Kozikowski AP, Wood PL, Reynolds IJ, Ball RG, Pang YP |title=Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes ofPCP's binding conformation. A new PCP-like compound with increased in vivo potency |journal=J Med Chem |year=1992| volume=35 |issue=9|pages=1634–8|doi=10.1021/jm00087a020] [cite journal| author=Elhallaoui M, Laguerre M, Carpy A, Ouazzani FC |title=Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode |journal=J Mol Model |year=2002 |volume= 8 |issue=2 |pages=65–72| doi=10.1007/s00894-001-0067-4]

References