JWH-081

Drugbox
IUPAC_name = 4-methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone

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PubChem = 10547208
DrugBank =
C=25|H=25|N=1|O=2
molecular_weight = 371.47 g/mol
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legal_status = Legal
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JWH-081 is an analgesic drug from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. [Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. "Drug and Alcohol Dependance" 2000; 60:133-140.] It is fairly selective for the CB₁ subtype, with affinity at this subtype approximately 10x the affinity at CB₂. [Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson ALS, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB₁ and CB₂ receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB₂ receptor agonists. "Bioorganic and Medicinal Chemistry". 2005; 13:89-112.]

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