5-Carboxamidotryptamine

Drugbox
IUPAC_name = 3-(2-aminoethyl)-1H-indole-5-carboxamide


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CAS_number= 74885-09-9
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PubChem= 1809
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C=11 | H=13 | N=3 | O=1
molecular_weight = 203.240 g/mol
smiles = C1=CC2=C(C=C1C(=O)N)C(=CN2)CCN
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5-Carboxamidotryptamine (5-CT) is a drug which acts as a non-selective agonist at several different serotonin receptors. It was initially thought to be selective for 5HT₁ [Saxena PR, Lawang A. A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors. "Archives Internationales de Pharmacodynamie et de Therapie". 1985 Oct;277(2):235-52. PMID 2933009] , but subsequent research showed that it also acts at 5HT₂, 5HT₃, [Wright CE, Angus JA. 5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets. "Journal of Cardiovascular Pharmacology". 1989 Apr;13(4):557-64. PMID 2470992] 5HT₅ and 5HT₇, [Yamada J, Sugimoto Y, Noma T, Yoshikawa T. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. "European Journal of Pharmacology". 1998 Oct 16;359(1):81-6. PMID 9831297] although its strongest effect is at the 5HT_1A subtype. [Thomas DR, Middlemiss DN, Taylor SG, Nelson P, Brown AM. 5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors. "British Journal of Pharmacology". 1999 Sep;128(1):158-64. PMID 10498847] However despite its lack of selectivity, 5-CT is still a useful compound and is widely used in scientific research.

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