Meclizine

Meclizine

drugbox
IUPAC_name = 1- [(4-chlorophenyl)- phenyl-methyl] -4- [(3-methylphenyl)methyl] piperazine


CAS_number = 569-65-3
ATC_prefix = A04
ATC_suffix = AB04
ATC_supplemental = ATC|R06|AE05
PubChem = 4034
DrugBank = APRD00354
C=25 | H=27 | Cl=1 | N=2
molecular_weight = 390.948 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life = 6 hours
pregnancy_US= B
legal_status = OTC (US)
routes_of_administration = Oral

Meclizine (proposed INN is meclozine) is an antihistamine considered to be an antiemetic. It is sold under the brand names of Bonine, Antivert and Postafen and is most commonly used to inhibit nausea and vomiting. An alternative to dimenhydrinate (Dramamine), meclizine is considered to be equally effective, but with reduced side effects.

Uses

Motion sickness

Meclizine is effective in inhibiting the symptoms of motion sickness, such as nausea, vomiting, and dizziness.

Vertigo

Meclizine may be effective in relieving vertigo experienced as a result of inner ear infections or other conditions.

Risks of use

Drowsiness

Drowsiness may result as a side effect of taking meclizine. While the effects are less than those of dimenhydrinate, users are advised not to operate heavy machinery while under the influence. The consumption of alcohol while under the influence of meclizine may result in additional drowsiness.

Anticholinergics

Due to its possible anticholinergic action, meclizine should be used carefully with patients who suffer from asthma, glaucoma, or an enlarged prostate gland.

External links

* [http://bioinf.charite.de/superdrug/fullinfo.php?cas=000569653 University of Berlin's Institute of Biochemistry]
* [http://www.numarkpharmacists.com/hn/Drug/Meclizine.htm Numark Pharmacies Information Page on Meclizine]
* [http://www.rxlist.com/cgi/generic/mecliz_wcp.htm Rxlist Medical Dictionary]


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Look at other dictionaries:

  • Méclizine — Général No CAS …   Wikipédia en Français

  • meclizine — [mek′lə zēn΄] n. [ ME(THYL BENZENE) + C(H)L(OROFORM) + I + (PIPERA)ZINE] an antihistamine, C25H27ClN2, used for treating nausea and motion sickness …   English World dictionary

  • meclizine — noun an antihistamine (trade name Antivert) used to treat or prevent motion sickness • Syn: ↑meclizine hydrochloride, ↑Antivert • Usage Domain: ↑trade name (for: ↑Antivert) • Hypernyms: ↑ …   Useful english dictionary

  • meclizine hydrochloride — noun an antihistamine (trade name Antivert) used to treat or prevent motion sickness • Syn: ↑meclizine, ↑Antivert • Usage Domain: ↑trade name (for: ↑Antivert) • Hypernyms: ↑ …   Useful english dictionary

  • meclizine — noun Etymology: methyl + chlor + izine (alteration of azine) Date: 1954 a drug C25H27ClN2 used usually in the form of its hydrochloride to treat vertigo and nausea (as in motion sickness) …   New Collegiate Dictionary

  • meclizine — /mek leuh zeen /, n. Pharm. a compound, C25H27ClN2, used for preventing nausea of motion sickness, pregnancy, etc. [1950 55; ME(THYLBENZENE) + C(H)L(OR) 2 + I + (PIPERA)ZINE] * * * …   Universalium

  • meclizine — noun A piperazine antihistamine considered to be an antiemetic. Syn: meclozine …   Wiktionary

  • meclizine — mec·li·zine or Brit mec·lo·zine mek lə .zēn n a drug used usu. in the form of its hydrated hydrochloride C25H27ClN2·2HCl·H2O to treat nausea and vertigo see ANTIVERT …   Medical dictionary

  • meclizine — n. (Medicine) antihistamine used to treat vomiting and dizziness (trade name Antivert) …   English contemporary dictionary

  • meclizine — mec·li·zine …   English syllables

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