Nabitan

Nabitan

Systematic (IUPAC) name
(-)-8-(1,2-Dimethylheptyl)-1,3,4,5-tetrahydro-5,5-dimethyl-2-(2-propynyl) -2H-(1)benzopyrano(4,3-c)pyridin-10-yl 1-piperidinebutyrate
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	66556-74-9
ATC code	None
PubChem	CID 39503
ChemSpider	36117 Y
Chemical data
Formula	C35H52N2O3
Mol. mass	548.799 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C35H52N2O3/c1-7-9-11-15-26(3)27(4)28-23-31(39-33(38)16-14-21-36-19-12-10-13-20-36)34-29-25-37(18-8-2)22-17-30(29)35(5,6)40-32(34)24-28/h2,23-24,26-27H,7,9-22,25H2,1,3-6H3 Y Key:MCVPMHDADNVRKF-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Nabitan (Nabutam, Benzopyranoperidine, SP-106, Abbott 40656) is a synthetic cannabinoid analog of dronabinol (Marinol).^[1] It exhibits antiemetic and analgesic effects, most likely by binding to and activating the CB₁ and CB₂ cannabinoid receptors, and reduced intraocular pressure in animal tests, making it potentially useful in the treatment of glaucoma.^[2]

Nabitan has the advantage of being water soluble unlike most cannabinoid derivatives, and was researched for potential use as an analgesic or sedative,^[3] although it was never developed for clinical use and is not currently used in medicine, as dronabinol or nabilone were felt to be more useful. However it is sometimes used in research into the potential therapeutic applications of cannabinoids.

Allosteric modulators of
cannabinoid receptors

Org 27569 · Org 27759 · Org 29647

Endocannabinoid
activity enhancers

AM-404 · CAY-10401 · CAY-10429 · JZL184 · JZL195 · Arachidonoyl serotonin · O-1624 · PF-04457845 · PF-622 · PF-750 · PF-3845 · PHOP · URB-447 · URB-597 · URB-602 · URB-754 · Genistein · Arvanil · Olvanil · Kaempferol · Biochanin A

Cannabinoid receptor
antagonists and
inverse agonists

AM-251 · AM-281 · AM-630 · BML-190 · CAY-10508 · CB-25 · CB-52 · CB-86 · Drinabant · Hemopressin · Ibipinabant (SLV319) · JTE-907 · LY-320,135 · Taranabant (MK-0364) · MK-9470 · NESS-0327 · O-1184 · O-1248 · O-2050 · O-2654 · Otenabant · Rimonabant (SR141716) · SR144528 · Surinabant (SR147778) · TM-38837 · VCHSR